Evidence map›Paper›PMID 41694261›Full record

ArticleF&S reports2026

A single biomarker may not yield a reliable binary clinical answer: B cell lymphoma 6 testing and resulting interventions for endometriosis in infertility care.

Arti Taggar, Amanda Ulrich, Yuliana Tan, Danielle E Luciano, Melinda Sanders, Elise T Courtois, Claudio Benadiva

Abstract read
In one paragraph

Article in F&S reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Arti TaggarReproductive Endocrinology and Infertility, Center for Advanced Reproductive Services, Farmington, Connecticut.
Amanda UlrichDepartment of Obstetrics and Gynecology, UCONN Health, Farmington, Connecticut.
Yuliana TanThe Jackson Laboratory for Genomic Medicine, Farmington, Connecticut.
Danielle E LucianoDepartment of Obstetrics and Gynecology, UCONN Health, Farmington, Connecticut.
Melinda SandersDepartment of Pathology and Laboratory Medicine, UCONN Health, Farmington, Connecticut.
Elise T CourtoisDepartment of Obstetrics and Gynecology, UCONN Health, Farmington, Connecticut.
Claudio BenadivaReproductive Endocrinology and Infertility, Center for Advanced Reproductive Services, Farmington, Connecticut.

Funding

Shared Resource ManagementP30CA034196 · NCI · JACKSON LABORATORY · PI Paul Robson · 1985 to 2026
$61.9M
NCI NIH HHS P30 CA034196
6 · The paper itself

Abstract

Objective: To study the associations of B cell lymphoma 6 (BCL6) in endometrial endometriosis, and to determine a practice's experience testing BCL6 in patients with recurrent pregnancy loss/recurrent implantation failure (RPL/RIF). Design: Retrospective chart review. Subjects: Endometrial samples were collected at the time of laparoscopy from 19 reproductive-aged individuals with known stage II-IV endometriosis. Endometrium biopsies were also collected from eight healthy controls, at a single academic center. Exposure: Results using standard immunohistochemical staining for BCL6 on endometrial biopsies from October 2019 to March 2023 were obtained. For the in vitro fertilization patients with a positive BCL6 result (HSCORE Main Outcome Measures: Outcomes for the embryo transfer cycle immediately after that biopsy/intervention were analyzed. Descriptive statistics with independent t-tests for continuous data, and χ Results: We found no significant upregulation of Conclusion: The relationship between BCL6 and endometriosis may not be the golden solution to a single marker focus for testing, or for subsequent therapy planning among infertility patients. Clinicians should be cautious in using single marker testing for diagnosing and treating endometriosis in patients without strong additional therapeutic evidence.

Indexed as

BCL6endometriosisrecurrent implantation failurerecurrent pregnancy loss

Identifiers

PMID41694261
PMCPMC12905616

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.