ArticleIranian endodontic journal2026
Osteogenic Response of Saos-2 Cells to Calcium Silicate-based versus Hydroxyapatite-based Cements: A Comparative Study.
Article in Iranian endodontic journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Introduction: Bioceramic materials are integral to regenerative endodontics, yet comparative data on their osteogenic potential remain limited. This study compared the osteogenic potential of four bioceramics: hydroxyapatite (HA), a nano-hydroxyapatite/chitosan composite (n-HA/CSS), Angelus mineral trioxide aggregate (MTA), and calcium-enriched mixture (CEM) cement. Materials and Methods: Human osteoblast-like Saos-2 cells were exposed to materials Results: All materials were non-cytotoxic. In direct culture, CEM significantly enhanced cell proliferation by day 3 (~3-fold, Conclusions: CEM and the n-HA/CS were identified as the strongest promoters of osteoblast proliferation and differentiation, indicating their superior bioactivity over MTA and HA and their potential for endodontic and surgical hard tissue regeneration.
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