Evidence map›Paper›PMID 41694133›Full record

ArticleFrontiers in bioengineering and biotechnology2025

Optimization of mannanase expression in

Hui Zhang, Huakai Tang, Tingting Ma, Xiaofei Ma, Yuwei Kou, Bing Wang, Jiahuan He, Jie Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Hui ZhangSchool of Life Sciences at Northeast Agricultural University, Harbin, China.
Huakai TangSchool of Life Sciences at Northeast Agricultural University, Harbin, China.
Tingting MaSchool of Life Sciences at Northeast Agricultural University, Harbin, China.
Xiaofei MaSchool of Life Sciences at Northeast Agricultural University, Harbin, China.
Yuwei KouSchool of Life Sciences at Northeast Agricultural University, Harbin, China.
Bing WangSchool of Life Sciences at Northeast Agricultural University, Harbin, China.
Jiahuan HeSchool of Life Sciences at Northeast Agricultural University, Harbin, China.
Jie LiSchool of Life Sciences at Northeast Agricultural University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mannan oligosaccharides (MOS) are high-value prebiotics widely applied in the food, feed, and pharmaceutical industries. Mannanase, as the key rate-limiting enzyme in the biosynthesis of MOS, directly determines MOS yield and production cost based on its expression level. However, current industrial enzyme sources commonly exhibit low expression levels, poor secretion efficiency, and inadequate stability, severely limiting the reliable production of high-performance enzyme preparations. To overcome this core bottleneck, this study employed

Indexed as

Aspergillus nigergene overexpressionmannanasemannan oligosaccharidessignal peptidesorting 10vacuolar protein

Identifiers

PMID41694133
PMCPMC12901352

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.