ArticleFrontiers in psychiatry2025
Electroconvulsive therapy for obsessive-compulsive disorder: clinical efficacy and predictive role of inflammatory markers.
Article in Frontiers in psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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6 authors.
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Abstract
Objective: This retrospective study aimed to evaluate the clinical efficacy of electroconvulsive therapy (ECT) in patients with obsessive-compulsive disorder (OCD) and identify potential predictive factors, focusing on inflammatory markers to optimize therapeutic outcomes. Methods: We retrospectively analyzed clinical data from 63 OCD patients who received ECT from January 2010 to August 2024. Clinical demographics, ECT parameters, and baseline blood cell counts were extracted from electronic medical records. Inflammatory indices were calculated accordingly. The Clinical Global Impressions-Improvement scale (CGI-I) was utilized to assess treatment outcomes. Patients were categorized into responders and non-responders based on CGI-I scores. Logistic regression analysis determined predictors of ECT efficacy, and the receiver operating characteristic (ROC) curve assessed the predictive capability of these factors. Results: Among the 63 patients, 46 (73.0%) responded positively to ECT. Responders had significantly more ECT sessions ( Conclusion: ECT is clinically effective for OCD, seizure duration was significantly associated with treatment outcomes. Although baseline NMR was not statistically significant in multivariate analysis, it holds potential predictive value, possibly limited by sample size and study design. Future larger-scale, prospective studies are warranted.
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