Evidence map›Paper›PMID 41694095›Full record

ArticleRSC advances2026

Biphasic dissolving microneedles with cyclodextrin inclusion complexes for enhanced delivery of poorly soluble drugs.

Runze Wang, Jiaqi Cao, Jing Zou, Rui Zhang, Mengmeng Li, Wanglong Zhang, Mintong Guo

Abstract read
In one paragraph

Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Runze WangSchool of Pharmaceutical Sciences, Zhengzhou University Zhengzhou Henan China guo5566@126.com.ORCID https://orcid.org/0009-0003-6497-8913
Jiaqi CaoSchool of Pharmaceutical Sciences, Zhengzhou University Zhengzhou Henan China guo5566@126.com.
Jing ZouSchool of Pharmaceutical Sciences, Zhengzhou University Zhengzhou Henan China guo5566@126.com.
Rui ZhangSchool of Pharmaceutical Sciences, Zhengzhou University Zhengzhou Henan China guo5566@126.com.
Mengmeng LiSchool of Pharmaceutical Sciences, Zhengzhou University Zhengzhou Henan China guo5566@126.com.
Wanglong ZhangSchool of Pharmaceutical Sciences, Zhengzhou University Zhengzhou Henan China guo5566@126.com.
Mintong GuoSchool of Pharmaceutical Sciences, Zhengzhou University Zhengzhou Henan China guo5566@126.com.ORCID https://orcid.org/0009-0004-0778-6891

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dissolving microneedles (DMNs) have been widely investigated for transdermal drug delivery, yet their clinical translation and commercialization remain limited, primarily due to insufficient drug-loading capacity. To address this challenge, we developed a high capacity platform by integrating hydroxypropyl-β-cyclodextrin (HP-β-CD) inclusion technology with a biphasic microneedle design for the delivery of flurbiprofen (FB), a model poorly soluble drug. Comprehensive characterization evaluated the morphology, mechanical strength, and

Identifiers

PMID41694095
PMCPMC12893894

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.