Evidence map›Paper›PMID 41693928›Full record

ArticleDigital health

The effectiveness of combining a home-based Digital motor Telerehabilitation program with conventional therapy in progressive multiple sclerosis: A study protocol for a multicenter, randomized controlled trial.

Marialuisa Gandolfi, Mauro Crestani, Gabriele Perachiotti, Francesca Salaorni, Andrea Baroni, Alberto Gajofatto, Riccardo Orlandi, Michela Rimondini, Valeria Donisi, Stefano Landi and 8 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Digital health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06485115 (The Effectiveness of Combining a Home-based Digital Motor Telerehabilitation Program With Conventional Therapy in Progressive Multiple Sclerosis), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06485115 naunknown statusnot on this map

The Effectiveness of Combining a Home-based Digital Motor Telerehabilitation Program With Conventional Therapy in Progressive Multiple Sclerosis: a Multicentre, Randomized Controlled Trial

TypeinterventionalSponsorUniversita di VeronaRan2024 to 2026Enrolled78ConditionsProgressive Multiple SclerosisArmsDigital Telerehabilitation (Euleria Home), Conventional therapy
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors.

Marialuisa GandolfiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-0877-4807
Mauro CrestaniDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0003-1175-4142
Gabriele PerachiottiDepartment of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
Francesca SalaorniDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Andrea BaroniDepartment of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.
Alberto GajofattoDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Riccardo OrlandiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Michela RimondiniDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Valeria DonisiDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Stefano LandiDepartment of Management, University of Verona, Verona, Italy.
Giovanni MoroneDepartment of Life, Health and Environmental Sciences, University of L'Aquila, L'Aquila, Italy.
Mirta FiorioDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Irene LozziDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-1756-0376
Nicola ValèDepartment of Engineering for Innovation Medicine, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-2364-5990
Ilaria SivieroDepartment of Engineering for Innovation Medicine, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0003-2974-1569
Silvia Francesca StortiDepartment of Engineering for Innovation Medicine, University of Verona, Verona, Italy.ORCID https://orcid.org/0000-0002-8605-803X
Nicola SmaniaDepartment of Neurosciences, Biomedicine and Movement Sciences, University of Verona, Verona, Italy.
Sofia StraudiDepartment of Neuroscience and Rehabilitation, University of Ferrara, Ferrara, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: The primary aim is to evaluate the effectiveness of in-hospital rehabilitation followed by a home-based Digital Telerehabilitation program on mobility versus in-hospital rehabilitation alone in patients with Progressive Multiple Sclerosis. Secondary aims are the intervention's impact on clinical, physiological, psychological, and economic outcomes. Methods: This multicenter, single-blind, randomized controlled trial will involve 78 participants with Progressive Multiple Sclerosis. All participants will complete 10 in-hospital rehabilitation sessions (1 hour/day, three days/week). The experimental group will receive an additional 12-week home-based Digital Telerehabilitation (3 sessions/week), while the control group general self-management instructions. Based on primary and secondary outcomes, a blinded rater will evaluate participants before and after rehabilitation and at 12 and 24 weeks follow-up. Results: Integrating home-based Digital Telerehabilitation is expected to mitigate the progression of disability, promote self-management, and reduce healthcare costs, offering a cost-effective and accessible solution for managing Progressive Multiple Sclerosis. Conclusions: This study will provide essential insights into the role of Digital Telerehabilitation in the hybrid care model to manage Progressive Multiple Sclerosis, with the potential to guide clinical practice and inform health policy. The physiological and economic evaluations will further clarify the benefits and cost-effectiveness of the intervention. Trial registration: This trial was registered in ClinicalTrials.gov (NCT06485115; URL: https://clinicaltrials.gov/study/NCT06485115?cond=NCT06485115&rank=1).

Indexed as

dual taskMultiple sclerosisquality of lifeTelerehabilitationwearables

Identifiers

PMID41693928
PMCPMC12895242

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.