Evidence map›Paper›PMID 41693906›Full record

ArticleBiomedical optics express2026

Correlation between diffuse correlation spectroscopy and transcranial Doppler ultrasound in pediatric sickle cell disease.

Giovani G Martins, Rowan O Brothers, Tisha Boodooram, Jada Oriahi, Tara M Urner, Labeausha Harris, Mariam Akbar, Shasha Bai, Beatrice E Gee, Clinton H Joiner and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Giovani G MartinsWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr NE, Atlanta, GA 30022, USA.ORCID https://orcid.org/0000-0001-6163-489X
Rowan O BrothersWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr NE, Atlanta, GA 30022, USA.
Tisha BoodooramWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr NE, Atlanta, GA 30022, USA.
Jada OriahiWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr NE, Atlanta, GA 30022, USA.
Tara M UrnerWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr NE, Atlanta, GA 30022, USA.ORCID https://orcid.org/0000-0001-7030-9255
Labeausha HarrisWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr NE, Atlanta, GA 30022, USA.
Mariam AkbarWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr NE, Atlanta, GA 30022, USA.
Shasha BaiDepartment of Pediatrics, Emory School of Medicine, Atlanta, GA 30322, USA.
Beatrice E GeeDepartment of Pediatrics, Emory School of Medicine, Atlanta, GA 30322, USA.
Clinton H JoinerDepartment of Pediatrics, Emory School of Medicine, Atlanta, GA 30322, USA.
Amy TangDepartment of Pediatrics, Emory School of Medicine, Atlanta, GA 30322, USA.
R Clark BrownIllexcor Therapeutics, LLC, 800 E Leigh St, Richmond, VA 23219, USA.
Erin M BuckleyWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr NE, Atlanta, GA 30022, USA.

Funding

Atlanta Network for Training In KUH Scientific Research (ATLANTIS)TL1DK136047 · NIDDK · EMORY UNIVERSITY · PI Vivien Andrea Sheehan · 2022 to 2026
$3.0M
Diffuse optical spectroscopies to assess cerebral hemodynamics in pediatric sickle cell diseaseR01HL152322 · NHLBI · EMORY UNIVERSITY · PI BUCKLEY, ERIN MCGUIRE, GEE, BEATRICE E · 2021 to 2024
$2.0M
NHLBI NIH HHS R01 HL152322NIDDK NIH HHS TL1 DK136047
6 · The paper itself

Abstract

Sickle cell disease causes alterations in cerebral blood flow (CBF) and a high risk of stroke. Monitoring CBF in these patients may provide valuable information about neurovascular compromise. Diffuse correlation spectroscopy (DCS) is a promising approach for non-invasively estimating an index of regional CBF; however, foundational studies are needed to validate DCS against clinical standards for estimating CBF in this clinical population. Here, we demonstrate that DCS significantly correlates with transcranial Doppler ultrasound-measured blood flow velocity in the anterior cerebral artery in 16 children with sickle cell disease (r = 0.82, p < 0.001). Correction for the influence of hematocrit on BFI did not significantly change this correction.

Identifiers

PMID41693906
PMCPMC12904537

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.