Dynamic Windkessel autoregulation for optical hemodynamic imaging: quantifying microcirculation, oxygen diffusion, and vascular autoregulation from low-frequency hemodynamic oscillations.

Yansen Hu, Yang Zheng, Kangyuan Yu, Ruobing Zhang, Mengdi Ma, Tinghua Gao, Jianmin Yang, Xin Jin, Weihao Lin, Min Xu

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Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Yansen HuInstitute of Lasers and Biomedical Photonics, Biomedical Engineering College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

Yang ZhengThe Second People's Hospital of Hefei, Hefei, Anhui 230011, China.

Kangyuan YuThe First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, China.

Ruobing ZhangInstitute of Lasers and Biomedical Photonics, Biomedical Engineering College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

Mengdi MaInstitute of Lasers and Biomedical Photonics, Biomedical Engineering College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

Tinghua GaoInstitute of Lasers and Biomedical Photonics, Biomedical Engineering College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

Jianmin YangInstitute of Lasers and Biomedical Photonics, Biomedical Engineering College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

Xin JinInstitute of Lasers and Biomedical Photonics, Biomedical Engineering College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

Weihao LinInstitute of Lasers and Biomedical Photonics, Biomedical Engineering College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.

Min XuInstitute of Lasers and Biomedical Photonics, Biomedical Engineering College, Wenzhou Medical University, Wenzhou, Zhejiang 325035, China.ORCID https://orcid.org/0000-0002-1245-2982

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hemodynamic-based neuroimaging and non-neuroimaging techniques are widely used in neuroscience and functional studies. Probing spontaneous or induced hemodynamic oscillations by light, such as coherent hemodynamics spectroscopy (CHS), has emerged as an effective approach for quantifying cerebral microcirculation and vascular autoregulation. We introduce dynamic Windkessel autoregulation, which enables noninvasive quantification of microcirculation, oxygen diffusion rates, and vascular autoregulation from low-frequency oscillations (LFOs). The model incorporates arteriole vasomotor responses to blood pressure variations and quantifies autoregulatory capacity using a dimensionless autoregulation gain index

Identifiers

PMID41693880

DOI10.1364/BOE.579339

PMCPMC12904564

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.