ArticleACS polymers Au2026
Blended and Microparticle Composite Hyaluronan Hydrogels with Programmable Degradation through Selective Oxidation.
Article in ACS polymers Au, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Crosslinking strategies govern the morphology and biological performance of decellularized extracellular matrix particle-tyramine-modified hyaluronic acid hydrogels.RSC advances · 2026Article
- Strategies and Technologies for Comprehensive Characterization of Hydrogel-Based Materials in the Biomedical Field.Polymers · 2026Review
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9 authors.
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Abstract
The design space of hydrogels for biomedical applications embraces a wide variety of parameters that can be tuned through chemical modification. Among them, tissue adhesion and viscoelastic properties contribute to the integration of tissue-engineered constructs with native tissues, while the degradation profile determines their temporal evolution and cell invasion. Selective 1,2-diol oxidation is a versatile tool to control all of these properties in polysaccharide-based hydrogels by generating aldehyde groups. A key challenge in implementing this tool is that although aldehyde groups improved adhesion, they also promoted chain fragmentation, demanding a trade-off. To address this, we devised a strategy that leverages the adhesiveness of oxidized biopolymers together with the mechanical stability of their nonoxidized counterparts. Here, we synthesized tyramine-modified hyaluronan (THA) and its oxidized form (oTHA) and evaluated their degradation and adhesion in various combinations and formats, including
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