Evidence map›Paper›PMID 41693805›Full record

ArticleOphthalmology science2026

Comparison of Deep Optic Nerve Head Structures and Optic Disc Morphology in Unilateral Peripapillary Intrachoroidal Cavitation.

Kaho Akiyama, Shuichiro Aoki, Shiroaki Shirato, Rei Sakata, Megumi Honjo, Makoto Aihara, Hitomi Saito

Abstract read
In one paragraph

Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Observational
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kaho AkiyamaDepartment of Ophthalmology, University of Tokyo Graduate School of Medicine, Shinjuku-ku, Tokyo, Japan.
Shuichiro AokiDepartment of Ophthalmology, University of Tokyo Graduate School of Medicine, Shinjuku-ku, Tokyo, Japan.
Shiroaki ShiratoYotsuya Shirato Eye Clinic, Shinjuku-ku, Tokyo, Japan.
Rei SakataDepartment of Ophthalmology, University of Tokyo Graduate School of Medicine, Shinjuku-ku, Tokyo, Japan.
Megumi HonjoDepartment of Ophthalmology, University of Tokyo Graduate School of Medicine, Shinjuku-ku, Tokyo, Japan.
Makoto AiharaDepartment of Ophthalmology, University of Tokyo Graduate School of Medicine, Shinjuku-ku, Tokyo, Japan.
Hitomi SaitoDepartment of Ophthalmology, University of Tokyo Graduate School of Medicine, Shinjuku-ku, Tokyo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To compare background characteristics, deep optic nerve head (ONH) structures, and optic disc morphology in participants with unilateral peripapillary intrachoroidal cavitation (PICC). Design: Retrospective cross-sectional study. Participants: One hundred six eyes of 53 participants with unilateral PICC determined on OCT. Methods: Twelve ONH-centered OCT radial slices were used to manually measure Bruch membrane opening (BMO) area, BMO ovality, scleral flange opening (SFO) area, SFO ovality, and SFO/BMO offset magnitude which represents the degree of SFO/BMO centroid displacement and clinically corresponds to the peripapillary atrophy-gamma and delta zones. Optic disc tilt, rotation, area, and longest and shortest diameters were measured from line scanning laser ophthalmoscopy images. Main Outcome Measures: Paired Results: Peripapillary intrachoroidal cavitation eyes showed significantly larger BMO area ( Conclusions: Although AL was similar between PICC eyes and their contralateral eyes, significant intereye differences in deep ONH structures and optic disc morphology were observed. Peripapillary intrachoroidal cavitation eyes exhibited a more elliptically expanded BMO, larger SFO, greater SFO/BMO misalignment, and greater optic disc tilt, which are structural changes associated with border tissue elongation. Our findings indicate a strong association between the presence of PICC and myopia-related characteristic deep ONH remodeling, providing a foundation for understanding structural abnormalities in myopic eyes. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Bruch membrane openingHigh myopiaOptic disc tiltPeripapillary atrophyScleral flange

Identifiers

PMID41693805
PMCPMC12902140

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.