Evidence map›Paper›PMID 41693773›Full record

ArticleFrontiers in pharmacology2026

Quercetin regulates autophagy and attenuates airway inflammation in a murine model of asthma: association with PI3K/Akt/mTOR signaling pathway modulation.

Liye Lang, Sheng Liu, Weishuai Zhang, Jialin Zhang, Hua Liu

Abstract read
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Article in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. In Vitro Anti-Breast Cancer Effects ofInternational journal of molecular sciences · 2026
    Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Liye Lang *Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Sheng Liu *Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Weishuai Zhang *Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Jialin ZhangDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.
Hua LiuDepartment of Respiratory and Critical Care Medicine, Affiliated Hospital of Nantong University, Medical School of Nantong University, Nantong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: As a natural flavonoid, quercetin has anti-inflammatory and anti-oxidative activities. Studies confirm its beneficial effect on asthma, but the underlying mechanism remains unclear. This study aimed to systematically evaluate quercetin's efficacy in treating asthma, explore its regulatory role in asthma-related autophagy and associated signaling pathways, and provide new insights for asthma treatment research. Methods: Results: Conclusion: Quercetin attenuates airway inflammation and lung damage in asthmatic mice. Its therapeutic effect is associated with the modulation of PI3K/Akt/mTOR signaling pathway activity and the regulation of excessive autophagy, which provides new potential approaches and mechanistic insights for asthma treatment.

Indexed as

asthmaautophagyinflammationPI3K signalingsquercetin

Identifiers

PMID41693773
PMCPMC12901423

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.