Evidence map›Paper›PMID 41693755›Full record

ArticlePhotoacoustics2026

Multi-parametric longitudinal imaging of cerebral biomarkers in a rodent model of Alzheimer's disease.

Tianqu Zhai, Wei Zhang, Chenshuo Ma, Linyu Ni, Yannis M Paulus, Enming Joseph Su, Geoffrey G Murphy, Daniel A Lawrence, Xueding Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Photoacoustics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Tianqu ZhaiDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Wei ZhangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Chenshuo MaDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Linyu NiDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Yannis M PaulusDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Enming Joseph SuDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Geoffrey G MurphyDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Daniel A LawrenceDepartment of Molecular and Integrative Physiology, University of Michigan Medical School, Ann Arbor, MI, USA.
Xueding WangDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.

Funding

Unraveling the role of tPA in the neurovascular unitR01HL055374 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI David Antonetti, Daniel A Lawrence · 1995 to 2026
$8.6M
Novel Early Retinal Imaging Biomarkers for Treating Later Spatial Memory Loss in Experimental Alzheimer's DiseaseR01AG081981 · NIA · WAYNE STATE UNIVERSITY · PI BRUCE A. BERKOWITZ · 2023 to 2026
$4.4M
The Role of PAI-1 in Cerebral Microvascular Dysfunction and the Development of Alzheimer’s Disease NeuropathologyR01AG074552 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAWRENCE, DANIEL A, MURPHY, GEOFFREY G · 2021 to 2025
$3.4M
Personalized Cancer Therapy Guided by Photoacoustic Chemical Imaging (PACI) of Tumor Microenvironment (TME)R01CA250499 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KLEER, CELINA G, WANG, XUEDING · 2020 to 2025
$3.1M
A Novel PAI-1 Function Drives Lung FibrosisR01HL163870 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Daniel A Lawrence, THOMAS H SISSON · 2023 to 2026
$2.8M
Wearable real-time functional brain mapping for a non-human primate stroke modelR01NS118918 · NINDS · UNIVERSITY OF KANSAS LAWRENCE · PI NUDO, RANDOLPH J., WANG, XUEDING · 2020 to 2024
$2.7M
Multimodal Molecular Imaging of Choroidal NeovascularizationR01EY034325 · NEI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Yannis Mantas Paulus, XUEDING WANG · 2023 to 2026
$2.5M
Development of Nanoneedle Array for Painless and Long-Term Sustained Intraocular Drug DeliveryR01EY033000 · NEI · PURDUE UNIVERSITY · PI LEE, CHI HWAN, PAULUS, YANNIS MANTAS · 2021 to 2025
$1.9M
Characterization and targeting of a novel pathway promoting Parkinson’s DiseaseR56NS132411 · NINDS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI LAWRENCE, DANIEL A · 2023 to 2023
$647k
NCI NIH HHS R01 CA250499NEI NIH HHS R01 EY033000NEI NIH HHS R01 EY034325NHLBI NIH HHS R01 HL055374NHLBI NIH HHS R01 HL163870NIA NIH HHS R01 AG074552NIA NIH HHS R01 AG081981NINDS NIH HHS R01 NS118918NINDS NIH HHS R56 NS132411
6 · The paper itself

Abstract

This study introduces a method for longitudinally monitoring Alzheimer's disease (AD)-related biomarkers in a rodent model utilizing a dual-modality imaging system combining photoacoustic microscopy (PAM) and confocal fluorescence microscopy (CFM). Using a cranial window transparent to both light and ultrasound, we examined cerebral vasculature, blood flow speed, oxygen saturation (sO

Indexed as

Alzheimer's diseaseBeta-amyloidFluorescence ImagingFunctional Photoacoustic microscopyLongitudinal monitoringNeurovascular Imaging

Identifiers

PMID41693755
PMCPMC12906206

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.