ReviewDEN open2026
Prophylactic Mechanical Closure for Preventing Delayed Bleeding after Gastric Endoscopic Submucosal Dissection: A Systematic Review and Meta-Analysis.
Review in DEN open, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed.
- A pilot study on the efficacy of cyanoacrylate glue in preventing post-ESD bleeding at the gastric angle.Surgical endoscopy · 2026Article
- Establishment and validation of a predictive scoring system for titanium clip retention at six months after endoscopic submucosal dissection for gastric lesions.Scientific reports · 2026Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Delayed bleeding remains the most common adverse event after gastric endoscopic submucosal dissection (ESD). We assessed whether prophylactic mechanical closure is associated with reduced clinically significant delayed bleeding. Methods: PubMed, Embase, Cochrane CENTRAL, Scopus, and ClinicalTrials.gov were searched through October 2025. Comparative studies reporting delayed bleeding within 30 days were included. Random-effects meta-analysis with Hartung-Knapp-Sidik-Jonkman adjustment was applied. Evidence certainty was assessed using GRADE. Results: Nine studies (2646 patients; eight non-randomized) met inclusion criteria. Prophylactic closure was associated with reduced delayed bleeding (risk ratio [RR] 0.36, 95% confidence interval [CI] 0.16-0.82; Conclusions: Prophylactic closure was associated with reduced delayed bleeding after gastric ESD; however, low-certainty evidence limits definitive conclusions. Well-designed randomized trials in high-risk populations are warranted to inform clinical practice. Trial Registration: PROSPERO registration: CRD420251172925.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.