ArticleFrontiers in immunology2025
Dahuang gancao dandelion decoction regulates intestinal flora and inhibits NF-κB/ARA signaling pathway to alleviate ulcerative colitis.
Article in Frontiers in immunology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Licorice Flavonoid Extract Ameliorates Intestine Damage in Ulcerative Colitis via MAPK/NF-κB Signaling Modulation and Gut Microbiome Remodeling.Foods (Basel, Switzerland) · 2026Article
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8 authors.
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Abstract
Objective: The aim of this study was to assess the therapeutic effects and underlying mechanisms of Dahuang Gancao Dandelion Decoction (DGD-D) on dextran sulfate sodium (DSS)-induced ulcerative colitis (UC) in a mice model, with an emphasis on modulation of gut microbiota and intestinal metabolites, maintenance of intestinal barrier integrity, and inhibition of inflammatory signaling pathways. Methods: Ultra-high-performance liquid chromatography with quadrupole electrospray ionization mass spectrometry (UHPLC-QE-MS) was used to examine the DGD-D, which was prepared from 40 g rhubarb, 10 g licorice, and 10 g dandelion. Potential routes and targets were found using network pharmacology. Six male C57BL/6 mice per group were randomized into control, DSS, DGD-D, and mesalazine (5-ASA) groups. UC was induced with 3% DSS for 7 days, with DGD-D administered prophylactically at 1950 mg/kg. Evaluated parameters included colon length, spleen index, and DAI, cytokine levels (ELISA, qRT-PCR), histological changes (H&E, PAS, AB-PAS), barrier proteins (IF, IHC, qRT-PCR), gut microbiota (16S rRNA sequencing), metabolites (LC-MS) and pathway validation. Results: UHPLC-QE-MS identified 418 components in DGD-D, including flavonoids (25.12%) and phenolic acids (9.33%). Network pharmacology highlighted NF-κB signaling as a key pathway. In comparison to DSS, DGD-D dramatically decreased spleen index, restored colon length, and decreased DAI scores ( Conclusion: DGD-D is a viable TCM-based treatment for UC since it improves DSS-induced UC by modifying gut microbiota and intestinal metabolites, reestablishing intestinal barrier function, and blocking the NF-κB/ARA pathway.
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