Evidence map›Paper›PMID 41693700›Full record

ReviewComprehensive reviews in food science and food safety2026

A Comprehensive Review of the Multitarget Effects of Subinhibitory Concentrations of Essential Oils Against Salmonella.

Carolina Ramos, Yhan S Mutz, Leticia Tessaro, Bruno Dutra da Silva, Marciane Magnani, Carlos Adam Conte-Junior

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Comprehensive reviews in food science and food safety, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Behavior ofInternational journal of food science · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Carolina RamosAnalytical and Molecular Laboratorial Center (CLAn), Institute of Chemistry (IQ), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil.
Yhan S MutzAnalytical and Molecular Laboratorial Center (CLAn), Institute of Chemistry (IQ), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil.
Leticia TessaroAnalytical and Molecular Laboratorial Center (CLAn), Institute of Chemistry (IQ), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil.
Bruno Dutra da SilvaAnalytical and Molecular Laboratorial Center (CLAn), Institute of Chemistry (IQ), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil.
Marciane MagnaniLaboratory of Microbial Processes in Foods, Department of Food Engineering, Center of Technology, Federal University of Paraíba, João Pessoa, Paraíba, Brazil.ORCID 0000-0002-7771-0479
Carlos Adam Conte-JuniorAnalytical and Molecular Laboratorial Center (CLAn), Institute of Chemistry (IQ), Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Rio de Janeiro, Brazil.ORCID 0000-0001-6133-5080

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 176408/2023-1Conselho Nacional de Desenvolvimento Científico e Tecnológico 313119/2020-1Coordenação de Aperfeiçoamento de Pessoal de Nível SuperiorFUNDAÇÃO AMPARO Á PESQUISA DO eSTADO DO RIO DE JANEIRO 26/200.738/2023FUNDAÇÃO AMPARO Á PESQUISA DO eSTADO DO RIO DE JANEIRO E- 26/200.891/2021Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/200.738/2023Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/200.891/2021Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/201.813/2022Fundação de Amparo à Pesquisa do Estado do Rio de Janeiro E-26/201.814/2022
6 · The paper itself

Abstract

Essential oils (EOs) exhibit antimicrobial activity against foodborne pathogens due to their chemical composition. This review investigates the mechanisms of action of EOs at subinhibitory concentrations against Salmonella strains. Even at subinhibitory concentrations, EOs induce cellular stress and modulate bacterial metabolism. EOs interfere with quorum sensing (QS) by downregulating genes (luxS, pdfs, sdiA, and qseB), which are essential for the system's function, affecting biofilm formation and virulence expression. Additionally, EOs act as antibiofilm agents, reducing cell adhesion and biomass of mature biofilms. At the molecular level, they regulate genes associated with biofilm formation (csgA, csgB, and csgD) and bacterial motility (motB, flhD, and fliZ). The combination of EOs with conventional antibiotics has shown synergistic effects. A proposed mechanism for this action is the inhibition of efflux pumps, which favors the retention of antimicrobial agents inside the cell. Despite promising results, challenges such as the sensory impact of high EOs concentrations and the need for further standardization in their application remain. Future research should focus on the long-term effects of subinhibitory concentrations of EOs, bacterial molecular response mechanisms, and the development of new delivery systems to optimize the efficacy of EOs.

Indexed as

Anti-Bacterial AgentsOils, VolatileSalmonellaBiofilmsQuorum SensingAnti-Bacterial AgentsOils, Volatilebiofilmefflux pumpessential oilsquorum sensingSalmonella

Identifiers

PMID41693700
PMCPMC12908213

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.