Evidence map›Paper›PMID 41693628›Full record

ArticleActa physiologica (Oxford, England)2026

Myophosphorylase Knock Out Prevents the Exaggerated Exercise Pressor Reflex in Rats With Simulated Peripheral Artery Disease.

Guillaume P Ducrocq, Laura Anselmi, Victor Ruiz-Velasco, Marc P Kaufman

Abstract read
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In one paragraph

Article in Acta physiologica (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Guillaume P DucrocqHeart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA.ORCID https://orcid.org/0000-0003-3531-4678
Laura AnselmiHeart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Victor Ruiz-VelascoHeart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA.
Marc P KaufmanHeart and Vascular Institute, Penn State College of Medicine, Hershey, Pennsylvania, USA.

Funding

Opioid-induced potentiation of the exercise pressor reflex via acid-sensing ion channels (ASIC3) in health and simulated peripheral artery diseaseR01HL156513 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI RUIZ-VELASCO, VICTOR · 2021 to 2024
$2.4M
Role played by Acid Ion Sensing Channels in Peripheral Artery DiseaseR01HL156594 · NHLBI · PENNSYLVANIA STATE UNIV HERSHEY MED CTR · PI KAUFMAN, MARC PETER, RUIZ-VELASCO, VICTOR · 2021 to 2024
$2.3M
Signaling pathways regulating mechanoreflex sensitization in cardiovascular diseaseR01HL161160 · NHLBI · KANSAS STATE UNIVERSITY · PI COPP, STEVEN W · 2022 to 2025
$2.1M
NHLBI NIH HHS R01 HL156513NHLBI NIH HHS R01HL156513NHLBI NIH HHS R01 HL156594NHLBI NIH HHS R01HL156594NHLBI NIH HHS R01 HL161160NHLBI NIH HHS R01HL161160
6 · The paper itself

Abstract

aimControversy exists on which metabolites determine the exaggerated exercise pressor reflex (EPR) in peripheral artery disease (PAD). In decerebrated rats, we investigated the role played by lactate and hydrogen ions in a model of PAD, which was simulated by ligating the femoral artery for 72 h before the start of the experiment.

methodsProduction of lactate and hydrogen ions by the contracting hindlimb muscles was manipulated by knocking out the myophosphorylase gene (pygm). In both knockout (pygm

resultsIn pygm

conclusionLactate and hydrogen-ions accumulation in contracting myocytes plays a key role in exaggerating the metabolic component of the EPR evoked from hindlimb muscles with chronically-ligated femoral arteries.

Indexed as

Peripheral Arterial DiseasePhysical Conditioning, AnimalReflexAnimalsBlood PressureDisease Models, AnimalFemaleHindlimbLactic AcidMaleMuscle ContractionMuscle, SkeletalRatsLactic Acidautonomic functionblood pressurechronic ischemialactatemetaboreflexmuscle acidosisperipheral artery diseasesympathetic activity

Identifiers

PMID41693628
PMCPMC12908092

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.