Trial reportArthritis care & research2026
Does Long-Term Lower Extremity Strength Training in Adults With Knee Osteoarthritis and Varus Alignment Reduce Knee Joint Loading During Gait?
Trial report in Arthritis care & research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- From paradox to population impact: Rethinking strengthening in knee osteoarthritis - A state-of-the-art review.Osteoarthritis and cartilage open · 2026Review
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
objectiveWe examined whether 18 months of strength training in individuals with knee varus alignment and medial tibiofemoral osteoarthritis (OA) reduced knee joint loads during walking compared to an attention control group.
methodsThis study was a secondary analysis of a randomized clinical trial that compared the effects of strength training to a control group in adults with knee OA. For this analysis, control participants had knee varus malalignment (≥2° varus; N = 49); participants in the strength training group met the varus malalignment criterion and increased their hip abductor strength by ≥20% from baseline to 18-month follow-up (N = 39). Linear regressions were used to compare means between groups at 18 months.
resultsThe strength training group had greater increases in strength in the quadriceps (45%), hamstrings (68%), and hip abductors (42%) than the control group (16%, 11%, 4%, respectively; P < 0.05). There were no significant differences in the mean peak internal knee abduction moment or mean peak knee compressive force between groups at 18-month follow-up. The adjusted means at 18-month follow-up for the internal knee extension moment were significantly less (27%) in the strength training group (P
conclusionAmong older adults with knee OA and varus alignment, long-term lower extremity strength training results in significant increases in strength but does not significantly alter most measures of knee joint loading during walking relative to an attention control group. The results cast doubt on whether clinically meaningful improvement in lower extremity muscle strength translates to clinically important attenuation in knee joint loading.
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