Evidence map›Paper›PMID 41693579›Full record

ArticleThe Laryngoscope2026

Effects of Deep Brain Stimulation on Adductor Laryngeal Dystonia.

Rita R Patel, Maggie Stall, Stacey Halum, Benjamin Anthony, Noah Parker, Morgan Reese, David Kareken, Stephanie Dickinson, Thomas C Witt, David A Purger and 2 more

Abstract read
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In one paragraph

Article in The Laryngoscope, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Rita R PatelDepartment of Otolaryngology Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.ORCID 0000-0002-5354-5210
Maggie StallDepartment of Speech, Language and Hearing Sciences, Indiana University, Bloomington, Indiana, USA.
Stacey HalumDepartment of Otolaryngology Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Benjamin AnthonyDepartment of Otolaryngology Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Noah ParkerDepartment of Otolaryngology Head and Neck Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Morgan ReeseDepartment of Medicine, Indiana University School of Medicine, Bloomington, Indiana, USA.
David KarekenDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Stephanie DickinsonDepartment of Epidemiology and Biostatistics, Indiana University School of Public Health, Bloomington, Indiana, USA.
Thomas C WittDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
David A PurgerDepartment of Neurological Surgery, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Kunal GuptaDepartment of Neurosurgery, Medical College of Wisconsin, Milwaukee, Wisconsin, USA.
S Elizabeth ZauberDepartment of Neurology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Funding

Quality Assurance and Quality Control Project Management: Improving Submissions and Study Conduct in the Human Subjects Research Prior Approval ProcessUL1TR002529 · NCATS · INDIANA UNIVERSITY INDIANAPOLIS · PI MOE, SHARON M, WIEHE, SARAH ELIZABETH · 2018 to 2022
$27.2M
NCATS NIH HHS UL1 TR002529NIH HHS UL1TR002529
6 · The paper itself

Abstract

objectiveTo examine the effects of globus pallidus interna (GPi) and ventral intermediate nucleus of the thalamus (VIM) deep brain stimulation (DBS) on patients with adductor laryngeal dystonia (ADLD).

methodsSeven patients with ADLD underwent DBS (GPi = 4; VIM = 3) surgery. Postoperative voice testing was performed after stable DBS programming. Primary outcome measures included tremor rate, extent of fundamental frequency/intensity modulation, percentage of voicing, duration/number of voice breaks, and cepstral peak prominence. Linear mixed effects models tested voice improvement after GPi and VIM surgery, with significance determined after controlling for multiple comparisons.

resultsGPi-DBS showed trends for improved percentage of voicing, duration of voice breaks, number of voice breaks, and extent of intensity modulation pre-post within-group with large effect size. VIM-DBS showed trends for improved tremor rate within-group with large effect size. Between-group comparison showed greater improvement in percentage voicing and extent of intensity modulation in patients with GPi-DBS compared to VIM-DBS, whereas tremor rate showed greater improvement after VIM-DBS compared to GPi-DBS. Duration of voice breaks showed more improvement in GPi than VIM but it did not achieve statistical significance after multiple comparison adjustments.

conclusionsObjective acoustic voice analyses provide preliminary, target-specific patterns that warrant confirmation of bilateral GPi-DBS for patients with ADLD and bilateral VIM-DBS for those with both ADLD and vocal tremor. Future research with larger sample sizes, along with investigations into the neuronal mechanisms underlying laryngeal neuromodulation, is needed to further evaluate the role of DBS in treating ADLD. LEVEL OF EVIDENCE: 3:

Indexed as

Deep Brain StimulationDystoniaLaryngeal DiseasesLaryngeal MusclesAdultAgedFemaleGlobus PallidusHumansMaleMiddle AgedTreatment OutcomeVentral Thalamic Nucleiadductor laryngeal dystoniaadductor spasmodic dysphoniadeep brain stimulationGPiVIM

Identifiers

PMID41693579
PMCPMC13253171

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.