Evidence map›Paper›PMID 41693575›Full record

ArticleCirculation2026

Novel Plasma Proteomic Markers and Risk of Venous Thromboembolism.

Weihong Tang, Aixin Li, Thomas R Austin, Sigrid K Brækkan, Therese H Nøst, Xumin Li, Rajat Deo, Ruth Dubin, Peter Ganz, Weihua Guan and 17 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors.

Weihong Tang *Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN (W.T., A.L., J.S.P., A.R.F.).ORCID 0000-0003-1200-0270
Aixin Li *Division of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN (W.T., A.L., J.S.P., A.R.F.).ORCID 0009-0006-9319-8790
Thomas R AustinCardiovascular Health Research Unit, Department of Epidemiology, University of Washington, Seattle, WA (T.R.A.).ORCID 0000-0003-2671-3706
Sigrid K BrækkanThrombosis Research Center (TREC), Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway (S.K.B., J.-B.H.).ORCID 0000-0002-9678-9696
Therese H NøstHUNT Research Center, Norwegian University of Science and Technology, Levanger, Norway (T.H.N., K.H., C.J.).ORCID 0000-0001-6805-3094
Xumin LiDepartment of Epidemiology, University of Washington, Seattle, WA (X.L., N.L.S.).ORCID 0000-0002-0547-7049
Rajat DeoDivision of Cardiovascular Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA (R. Deo).ORCID 0000-0002-8250-2607
Ruth DubinDivision of Nephrology, University of Texas Southwestern Medical Center, Dallas, TX (R. Dubin).ORCID 0000-0002-0498-1980
Peter GanzDivision of Cardiology, University of California, San Francisco, San Francisco, CA (P.G.).ORCID 0000-0002-0437-8882
Weihua GuanDivision of Biostatistics & Health Data Science, University of Minnesota, Minneapolis, MN (W.G., R.C.).ORCID 0000-0002-0956-9821
Rui CaoDivision of Biostatistics & Health Data Science, University of Minnesota, Minneapolis, MN (W.G., R.C.).ORCID 0009-0005-5157-2396
John-Bjarne HansenThrombosis Research Center (TREC), Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway (S.K.B., J.-B.H.).
Kristian HveemHUNT Research Center, Norwegian University of Science and Technology, Levanger, Norway (T.H.N., K.H., C.J.).ORCID 0000-0001-8157-9744
Ron C HoogeveenDivision of Cardiovascular Research, Department of Medicine, Baylor College of Medicine, Houston, TX (R.C.H.).ORCID 0000-0003-2399-4653
Christian JonassonHUNT Research Center, Norwegian University of Science and Technology, Levanger, Norway (T.H.N., K.H., C.J.).ORCID 0000-0002-7694-6025
Jerome I RotterThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.I.R., K.D.T.).ORCID 0000-0001-7191-1723
Kunihiro MatsushitaDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD (K.M.).ORCID 0000-0002-7179-718X
Guning LiuDepartment of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center, School of Public Health, Houston, TX (G.L., E.B.).
James S PankowDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN (W.T., A.L., J.S.P., A.R.F.).ORCID 0000-0001-7076-483X
Nathan PankratzDepartment of Laboratory Medicine and Pathology, University of Minnesota Medical School, Minneapolis, MN (N.P.).ORCID 0000-0001-5958-693X
Bruce M PsatyCardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Systems and Population Health, University of Washington, Seattle, WA (B.M.P.).ORCID 0000-0002-7278-2190
Kent D TaylorThe Institute for Translational Genomics and Population Sciences, Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, Torrance, CA (J.I.R., K.D.T.).ORCID 0000-0002-2756-4370
Florian ThibordINSERM UMR 1219, Bordeaux Population Health Research Center, Bordeaux, France (F.T.).ORCID 0000-0003-2229-8322
Eric BoerwinkleDepartment of Epidemiology, Human Genetics and Environmental Sciences, The University of Texas Health Science Center, School of Public Health, Houston, TX (G.L., E.B.).ORCID 0000-0001-8813-0544
Nicholas L SmithDepartment of Epidemiology, University of Washington, Seattle, WA (X.L., N.L.S.).ORCID 0000-0003-3483-353X
Mary CushmanDepartment of Pathology and Laboratory Medicine, Larner College of Medicine, University of Vermont, Burlington, VT (M.C.).ORCID 0000-0002-7871-6143
Aaron R FolsomDivision of Epidemiology & Community Health, School of Public Health, University of Minnesota, Minneapolis, MN (W.T., A.L., J.S.P., A.R.F.).ORCID 0000-0003-2635-2699

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Institute for Clinical and Translational Research (UL1)UL1RR025005 · NCRR · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2007 to 2011
$75.8M
Institute for Clinical and Translational ResearchUL1TR001079 · NCATS · JOHNS HOPKINS UNIVERSITY · PI FORD, DANIEL ERNEST · 2013 to 2017
$60.1M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4M
Wake Forest Clinical and Translational Science AwardUL1TR001420 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI ARD, JAMY D, FOLEY, KRISTIE L · 2015 to 2023
$32.3M
Clinical and Translational Science AwardUL1TR000040 · NCATS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2012 to 2015
$26.2M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Task Area A Core Study Operations.Task Area A shall encompass annual follow-up of cohort members, clinical endpoints ascertainment, study coordination activities, maintenance of the database and biosp75N92020D00001 · NHLBI · UNIVERSITY OF WASHINGTON · PI MCCLELLAND, ROBYN LEAGH · 2020 to 2025
$17.2M
Epidemiology of Venous Thrombosis & Pulmonary EmbolismR01HL059367 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TANG, WEIHONG · 1998 to 2024
$11.8M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
CARDIOVASCULAR HEALTH STUDY (CHS) - TASK AREA C, STUDY CLOSEOUT75N92021D00006 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE · 2021 to 2024
$8.4M
NCATS NIH HHS UL1 TR000040NCATS NIH HHS UL1 TR001079NCATS NIH HHS UL1 TR001420NCATS NIH HHS UL1 TR001881NCRR NIH HHS UL1 RR025005NHGRI NIH HHS U01 HG004402NHLBI NIH HHS 75N92020D00001NHLBI NIH HHS 75N92020D00002NHLBI NIH HHS 75N92020D00003NHLBI NIH HHS 75N92020D00004NHLBI NIH HHS 75N92020D00005NHLBI NIH HHS 75N92020D00006NHLBI NIH HHS 75N92020D00007NHLBI NIH HHS 75N92021D00006NHLBI NIH HHS HHSN268200800007CNHLBI NIH HHS HHSN268201200036CNHLBI NIH HHS HHSN268201500003CNHLBI NIH HHS HHSN268201500003INHLBI NIH HHS HHSN268201700001CNHLBI NIH HHS HHSN268201700001INHLBI NIH HHS HHSN268201700002CNHLBI NIH HHS HHSN268201700002INHLBI NIH HHS HHSN268201700003CNHLBI NIH HHS HHSN268201700003INHLBI NIH HHS HHSN268201700004CNHLBI NIH HHS HHSN268201700004INHLBI NIH HHS HHSN268201700005CNHLBI NIH HHS HHSN268201700005INHLBI NIH HHS HHSN268201800001CNHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085086NHLBI NIH HHS N01 HC095159NHLBI NIH HHS N01 HC095160NHLBI NIH HHS N01 HC095161NHLBI NIH HHS N01 HC095162NHLBI NIH HHS N01 HC095163NHLBI NIH HHS N01 HC095164NHLBI NIH HHS N01 HC095165NHLBI NIH HHS N01 HC095166NHLBI NIH HHS N01 HC095167NHLBI NIH HHS N01 HC095168NHLBI NIH HHS N01 HC095169NHLBI NIH HHS N02 HL064278NHLBI NIH HHS R01 HL059367NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL087641NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL132320NHLBI NIH HHS R01 HL134320NHLBI NIH HHS R01 HL144483NHLBI NIH HHS R01 HL155209NHLBI NIH HHS R01 HL159081NHLBI NIH HHS R01 HL172803NHLBI NIH HHS U01 HL080295NHLBI NIH HHS U01 HL130114NIA NIH HHS R01 AG023629NIA NIH HHS RF1 AG063507NIDDK NIH HHS P30 DK063491Wellcome Trust
6 · The paper itself

Abstract

backgroundVenous thromboembolism (VTE) is a leading cardiovascular disease, yet its etiology is incompletely understood. This study used large-scale, high-throughput aptamer-based proteomics to identify new circulating protein biomarkers and biological pathways for incident VTE.

methodsWe included 4 longitudinal cohorts (the ARIC study [Atherosclerosis Risk in Communities], CHS [Cardiovascular Health Study], MESA [Multi-Ethnic Study of Atherosclerosis], and the HUNT study [Trøndelag Health]) that identified 1371 incident noncancer VTEs among 20 737 participants followed for a maximum of 10 to 29 years. We used the SomaScan to measure baseline plasma levels of ≈5000 to 7000 proteins and examined the prospective relationships between the protein biomarkers and noncancer VTE. We then conducted an external replication of top VTE proteins in 783 incident noncancer VTEs among 39 097 participants in the UKB study (UK Biobank) based on the Olink proteomics platform. We used Cox proportional hazards regression to estimate the association between each protein biomarker and VTE risk. Mendelian randomization (MR) analysis was used to assess the possible causal associations between identified proteins and VTE risk.

resultsThere were 23 proteins that exceeded a false discovery rate-adjusted

conclusionsWe identified several novel plasma proteins for VTE that reflect biological processes outside established VTE pathophysiology, including extracellular matrix regulation, immunity, immune-vascular endothelium interactions, and vascular senescence. Results may provide new modifiable targets to improve VTE risk stratification, prevention, or treatment.

Indexed as

Blood ProteinsProteomicsVenous ThromboembolismAgedBiomarkersFemaleHumansLongitudinal StudiesMaleMendelian Randomization AnalysisMiddle AgedProspective StudiesRisk FactorsBiomarkersBlood Proteinsbiomarkersetiologyproteomicsrisk factorsvenous thromboembolism

Identifiers

PMID41693575
PMCPMC12991346

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.