Evidence map›Paper›PMID 41693466›Full record

ArticleGut microbes2026

Novel bacterium

Yao Zeng, Yao Huang, Silin Ye, Effie Yin Tung Lau, Man Chun Chiu, Linda Fenske, Yuting Sun, Liting Jiang, Jiangying Chen, Yanqing Huang and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Yao ZengDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Yao HuangDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Silin YeDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Effie Yin Tung LauDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Man Chun ChiuDepartment of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.
Linda FenskeBioinformatics and Systems Biology, Justus Liebig University, Giessen, Germany.
Yuting SunDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Liting JiangGuangzhou Institute of Microbiology Group Co., Ltd., Guangzhou, People's Republic of China.
Jiangying ChenGuangzhou Institute of Microbiology Group Co., Ltd., Guangzhou, People's Republic of China.
Yanqing HuangSecond Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, People's Republic of China.
Tingyu ZhouDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Jiawei LuDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.
Jie ZhouDepartment of Microbiology, School of Clinical Medicine, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, People's Republic of China.
Shu ZhengSecond Affiliated Hospital, Zhejiang University College of Medicine, Hangzhou, People's Republic of China.
Francis Ka Leung ChanDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.ORCID 0000-0001-7388-2436
Jessie Qiaoyi LiangDepartment of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, CUHK Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, People's Republic of China.ORCID 0000-0001-8496-3442

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe bacterial marker 'm3' shows promise for the non-invasive diagnosis of colorectal cancer (CRC) and adenomas. However, the m3-harboring bacterium (M3) had not been successfully cultured.

objectiveThis study aims to elucidate the functional mechanisms of M3 in CRC.

designM3 was isolated using a targeted enrichment strategy. Its functional roles were investigated

resultsM3 is phylogenetically related to

conclusionsThis study identifies M3 as a novel pro-tumorigenic bacterium in CRC, capable of direct biosynthesis of the carcinogenic metabolite styrene. We provide the first evidence of bacterial styrene biosynthesis, unveiling a previously unrecognized mechanism by which gut bacteria may promote colorectal tumorigenesis.

Indexed as

CarcinogenesisCarcinogensColorectal NeoplasmsStyreneAnimalsCell Line, TumorCell ProliferationFecesFemaleHumansMaleMiceMice, Inbred C57BLCarcinogensStyrenecolorectal cancerEnterocloster aldenensisstyrene

Identifiers

PMID41693466
PMCPMC12915766

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.