Evidence map›Paper›PMID 41693370›Full record

ArticleSmall (Weinheim an der Bergstrasse, Germany)2026

Spatiotemporal Co-Delivery of Hydrogen and Magnesium via Microneedle Patches for Neuroinflammation Modulation After Spinal Cord Injury: A Multi-Modal In Vivo Study.

Haibo Wang, Yang Sun, Shiqi Wang, Wenbo Wang, Jincheng Tang, Ziang Li, Xinzhao Jiang, Liang Zhou, Jie Wu, Qiangqiang Guo and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Small (Weinheim an der Bergstrasse, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Haibo WangDepartment of Orthopedics, First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, P. R. China.
Yang SunDepartment of Orthopedics, First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, P. R. China.
Shiqi WangSchool of Biomedical Engineering, Suzhou Institute for Advanced Research, University of Science and Technology of China, Jiangsu, P. R. China.
Wenbo WangDepartment of Orthopedics, First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, P. R. China.
Jincheng TangDepartment of Orthopedics, First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, P. R. China.
Ziang LiDepartment of Orthopedics, First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, P. R. China.
Xinzhao JiangDepartment of Orthopedics, First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, P. R. China.
Liang ZhouDepartment of Orthopedics, First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, P. R. China.
Jie WuDepartment of Orthopedics, First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, P. R. China.
Qiangqiang GuoDepartment of Orthopedics, First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, P. R. China.ORCID https://orcid.org/0009-0000-8782-7833
Yiwei ZhuDepartment of Orthopedics, First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, P. R. China.
Yu FengDepartment of Orthopedics, First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, P. R. China.
Kun XiDepartment of Orthopedics, First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, P. R. China.ORCID https://orcid.org/0000-0002-0458-9866
Liang ChenDepartment of Orthopedics, First Affiliated Hospital of Soochow University, Orthopedic Institute, Soochow University, Suzhou, Jiangsu, P. R. China.

Funding

China Postdoctoral Science Foundation 2025M782215National Natural Science Foundation of China 82120108017National Natural Science Foundation of China 82272501National Natural Science Foundation of China 82302683National Natural Science Foundation of China 82372484National Natural Science Foundation of China 82572769Natural Science Foundation of Jiangsu Province BK20230215Natural Science Foundation of Jiangsu Province BK20250123Outstanding Young Scholars Lead Project SSD2025025Project 333 of Jiangsu Province 2069999Soochow University Medical +X project ML12202923Suzhou Gusu Health Talent Program GSWS2023093
6 · The paper itself

Abstract

Spinal cord injury (SCI) treatment is hindered by a "triple barrier:" the physical dura, a chemical storm of reactive oxygen species (ROS), and an immune barrier mediated by pro-inflammatory microglia. To address these, we developed a "Hydrogen/Magnesium dual-engine microneedle" (MN-Mg) system by embedding magnesium (Mg) microparticles within a methacrylated hyaluronic acid (HAMA) hydrogel matrix via micromolding. Possessing high mechanical strength, Mg-MNs penetrate the dura mater. Upon implantation, the system triggers a controllable magnesium-water reaction, initiating a spatiotemporally synergistic dual-engine therapeutic mode. The "hydrogen engine" rapidly releases high-concentration hydrogen gas (H

Indexed as

HydrogenMagnesiumNeuroinflammatory DiseasesSpinal Cord InjuriesAnimalsFemaleMicrogliaMicroneedle Drug DeliveryRatsRats, Sprague-DawleyReactive Oxygen SpeciesHydrogenMagnesiumReactive Oxygen Specieshydrogen gasmagnesiummicrogliamicroneedlesneuroregenerationoxidative stressspinal cord injuries

Identifiers

PMID41693370
PMCPMC13081100

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.