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BUN and mortality in patients with heparin-induced thrombocytopenia: A retrospective cohort study.
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Abstract
IntroductionHeparin-induced thrombocytopenia (HIT) is a severe complication of heparin treatment, characterized by low platelet counts and heightened thrombotic risk. Blood urea nitrogen (BUN), which serves as an indicator of both renal function and illness severity, has been associated with poor outcomes in different contexts. However, its association with mortality in HIT remains poorly understood. Our study aimed to explore this relationship in critically ill patients with HIT.MethodsThis study was a retrospective cohort analysis utilizing the MIMIC-IV 3.1 database from 2008 to 2019. Patients with HIT were pinpointed through ICD codes. Those without BUN data or whose intensive care unit (ICU) admission was not their first were excluded. The main outcome measured was all-cause mortality, evaluated at multiple time points. The associations were examined using multivariate Cox regression models and Kaplan-Meier survival analysis.ResultsThe research encompassed 246 individuals with HIT (average age 66.2 years, 54.9% male). BUN levels showed a significant association with all-cause mortality during the hospital stay (HR 1.01, 95% CI 1.01-1.02,
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