Evidence map›Paper›PMID 41693305›Full record

ArticleACS nano2026

Multiscale Simulations and Cryo-Electron Microscopy Reveal the Transition Pathway of Dengue Virus-like Particle Nanoassembly.

Venkata Raghuvamsi Palur, Guan-Wen Chen, Day-Yu Chao, Wen-Shuo Kuo, Ya-Na Wu, Jedhan U Galula, Chun-Hsiung Wang, Fan-Chi Chen, Peter J Bond, Jan K Marzinek and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Venkata Raghuvamsi PalurBioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore.ORCID 0000-0002-0897-6935
Guan-Wen ChenSchool of Dentistry & Institute of Oral Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Day-Yu ChaoGraduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung 40227, Taiwan.
Wen-Shuo KuoCenter for Allergy Immunology and Microbiome (AIM), China Medical University Children's Hospital/China Medical University Hospital, China Medical University, Taichung 40447, Taiwan.
Ya-Na WuSchool of Dentistry & Institute of Oral Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.
Jedhan U GalulaGraduate Institute of Microbiology and Public Health, College of Veterinary Medicine, National Chung Hsing University, Taichung 40227, Taiwan.
Chun-Hsiung WangInstitute of Biological Chemistry, Academia Sinica, Taipei 11529, Taiwan.
Fan-Chi ChenMicrobial Genomics PhD Program, National Chung Hsing University and Academia Sinica, Taichung 40227, Taiwan.
Peter J BondBioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore.ORCID 0000-0003-2900-098X
Jan K MarzinekBioinformatics Institute (BII), Agency for Science, Technology and Research (A*STAR), 30 Biopolis Street, #07-01 Matrix, Singapore 138671, Republic of Singapore.ORCID 0000-0002-5493-8753
Shang-Rung WuSchool of Dentistry & Institute of Oral Medicine, College of Medicine, National Cheng Kung University, Tainan 70101, Taiwan.ORCID 0000-0003-1940-7612

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Dengue virus (DENV) continues to impose a global health burden, and virus-like particles (VLPs) are promising vaccine candidates, owing to their ability to elicit broadly neutralizing antibodies. However, the lack of nanoscale structural insights into the VLP maturation process has limited rational engineering. Here, we report the cryo-electron microscopy (cryo-EM) structure of immature DENV serotype 2 VLPs, revealing prM-E spikes arrayed on a

Indexed as

Cryoelectron MicroscopyDengue VirusMolecular Dynamics SimulationVaccines, Virus-Like ParticleVirionAnimalsVaccines, Virus-Like ParticleCHO-K1 cell linecryo-EMdengue virus-like particlesmaturation transitionmolecular dynamics simulations

Identifiers

PMID41693305
PMCPMC12961931

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.