Evidence map›Paper›PMID 41693220›Full record

Trial reportJournal of cosmetic dermatology2026

Intralesional Interferon Alfa-2b Versus Cryotherapy for Common Warts on the Hands and Feet: A Randomized, Open-Label, Controlled Trial.

Yi Jin, Xiaoming Shen

Abstract readRandomized Controlled TrialComparative Study
In one paragraph

Trial report in Journal of cosmetic dermatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Trial
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Yi JinDepartment of Dermatology, Suzhou Ninth People's Hospital (Suzhou Ninth Hospital Affiliated to Soochow University), Suzhou, China.
Xiaoming ShenDepartment of Dermatology, Suzhou Ninth People's Hospital (Suzhou Ninth Hospital Affiliated to Soochow University), Suzhou, China.ORCID https://orcid.org/0009-0009-5682-4088

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the clinical efficacy of interferon injection therapy for common warts on the hands and feet and to analyze its associated adverse reactions.

methodsA total of 326 patients with common warts located on the hands and feet who were treated at our hospital between January 2024 and February 2025 were enrolled. Using a block randomization method, the patients were divided into a control group (n = 163, treated with cryotherapy) and an observation group (n = 163, treated with intralesional interferon alfa-2b injection). The two groups were compared in terms of clinical efficacy, number, thickness, and diameter of warts, immune function, quality of life, adverse reactions, and recurrence rates.

resultsAfter treatment, the number, thickness, and diameter of warts decreased in both groups, with significantly greater reductions in the observation group. Post-treatment levels of cluster of differentiation 3 positive (CD3

conclusionInterferon injection therapy demonstrates clinical efficacy in the treatment of common warts on the hands and feet.

Indexed as

CryotherapyFoot DermatosesHand DermatosesInterferon alpha-2WartsAdolescentAdultFemaleFootHandHumansInjections, IntralesionalMaleMiddle AgedQuality of LifeRecurrenceInterferon alpha-2adverse reactionscommon wartsefficacyhands and feetinjection therapyinterferon

Identifiers

PMID41693220
PMCPMC12907598

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.