ArticlePediatric endocrinology, diabetes, and metabolism2025
Spontaneous final adult height in patients with idiopathic short stature.
Article in Pediatric endocrinology, diabetes, and metabolism, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionIdiopathic short stature (ISS) is defined as a height more than two standard deviations (SD) below the mean for age and sex for population group without evidence of a systemic, endocrine, nutritional, or genetically determined disorder. The study aimed to analyze the final height (FH) in a group of patients with ISS. MATERIAL AND
methodsThe inclusion criteria were as follows: • height < -2 SD or difference between height and target height (TH) calculated based on parents' height more than -1 SD; • growth hormone secretion above 10 ng/ml in stimulation tests or after falling asleep; • absence of chronic diseases that could be the cause of short stature; • Turner syndrome excluded, and lack of signs suggesting other genetically determined disorders. We evaluated the auxological data of 16 patients among 22 patients with ISS (13 girls and 3 boys) who completed the growth process.
resultsThe mean FH in the study group was 150.9 cm, the mean FH SDS was -2.85. Statistical analysis revealed a positive correlation between FH and predicted adult height based on prepubertal bone age (r = 0.905, p < 0.001) and a second evaluation of bone age (r = 0.780, p = 0.13). Statistical analysis revealed a positive correlation between FH SDS and height SD score (height SDS) at the age of 4 and 6 years (r = 0.749, p = 0.033 and r = 0.946, p < 0.001).
conclusionsPredicted adult height on prepubertal bone age and the height standard deviation score at the age of 4 years and 6 years can help estimate final height in a group of patients with idiopathic short stature.
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