ArticleJournal of analytical toxicology2026
GC-FID quantification of methanol, ethanol, 2-propanol, acetone, ethylene glycol, diethylene glycol, 1,2-propylene glycol and 1,3-propylene glycol in plasma.
Article in Journal of analytical toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Metabolic engineering of Escherichia coli for methanol-assisted resveratrol biosynthesis.Bioprocess and biosystems engineering · 2026Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alcohol and glycol ingestion, including substances such as methanol, ethylene glycol, and isopropanol, constitute a serious medical emergency that requires prompt diagnosis and treatment of patients. Rapid and accurate quantification of these compounds in plasma is essential to guide clinical decision-making and prevent delays in treatment that could result in irreversible organ damage or death. Many healthcare facilities lack analytical methods capable of simultaneously quantifying both alcohols and glycols in a single run. This study describes the development and validation of a rapid gas chromatography-flame ionization detection (GC-FID) method for the simultaneous screening and quantification of methanol, ethanol, 2-propanol, acetone, ethylene glycol, diethylene glycol, 1,2-propylene glycol, and 1,3-propylene glycol in human plasma. Plasma samples were prepared using a protein precipitation technique with acetonitrile containing two internal standards: 2-butanol and 1,4-butanediol. Acetonitrile effectively precipitated plasma proteins. The supernatant was then subjected to GC-FID analysis for quantification of the target al.ohols and glycols. The total analytical run time was 5 minutes, enabling the quantification of eight analytes in a single injection. The method demonstrated excellent linearity, with correlation coefficients (R2) exceeding 0.9995 for all compounds. The linear dynamic range was 40-1280 mg/L for methanol, 2-propanol, acetone, ethylene glycol, diethylene glycol, 1,2-propylene glycol, and 1,3-propylene glycol, and 80-2560 mg/L for ethanol. Within-run and between-run precision and accuracy (CV and bias) for all analytes were within the predefined acceptance criteria of ±15%. No significant interference, carry-over, or matrix effects were observed, confirming the method's selectivity and robustness. The developed GC-FID method enables rapid, accurate, and simultaneous quantification of toxic alcohols and glycols in plasma within a 5-minute run time. The excellent linearity, precision, and selectivity of the method met al. analytical performance criteria, making it well-suited for routine clinical use. This method provides a valuable tool for timely diagnosis and management of suspected toxic alcohol and glycol ingestions in patients in emergency settings.
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