Evidence map›Paper›PMID 41692976›Full record

ArticleDiabetic medicine : a journal of the British Diabetic Association2026

Association between diabetes and in-hospital outcomes in patients with metabolic dysfunction-associated steatotic liver disease hospitalized for cardiovascular disease: A nationwide database study.

Soichi Komaki, Michikazu Nakai, Yunosuke Matsuura, Kinuko Yamamoto, Hiroki Tanaka, Yuri Komaki, Masashi Yamaguchi, Kohei Moribayashi, Takeshi Ideguchi, Hiroshi Kawakami and 2 more

Abstract read
In one paragraph

Article in Diabetic medicine : a journal of the British Diabetic Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Soichi KomakiDivision of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.ORCID https://orcid.org/0000-0003-4946-2313
Michikazu NakaiClinical Research Support Center, University of Miyazaki Hospital, Miyazaki, Japan.
Yunosuke MatsuuraDivision of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.ORCID https://orcid.org/0000-0003-2927-7284
Kinuko YamamotoDivision of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Hiroki TanakaDivision of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Yuri KomakiDivison of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Masashi YamaguchiDivision of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Kohei MoribayashiDivision of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Takeshi IdeguchiDivision of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Hiroshi KawakamiDivison of Gastroenterology and Hepatology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Toshihiro TsurudaCardiorenal Research Laboratory Department of Hemo-Vascular Advanced Medicine Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Koichi KaikitaDivision of Cardiovascular Medicine and Nephrology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.

Funding

Grant for Clinical Research from the University of Miyazaki Hospital.
6 · The paper itself

Abstract

aimsTo evaluate the impact of diabetes on in-hospital outcomes among patients with metabolic dysfunction-associated steatotic liver disease (MASLD) who were hospitalized for cardiovascular disease (CVD).

methodsWe conducted a retrospective cross-sectional study using data from the nationwide Japanese Registry of All Cardiac and Vascular Diseases-Diagnosis Procedure Combination, from April 2012 to March 2023. A total of 10,614 patients with MASLD hospitalized for CVD were identified, of whom 4550 (42.9%) had diabetes. The primary outcome was in-hospital mortality, and secondary outcomes were major cardiac and non-cardiac complications.

resultsThe median age was 66 years, and 66.9% were male. Compared with patients without diabetes, those with diabetes had higher rates of ischaemic heart disease (35.5% vs. 30.8%), acute coronary syndrome (18.8% vs. 16.9%) and heart failure (27.3% vs. 25.4%) (all p < 0.05). In-hospital mortality (5.6% vs. 3.3%; p < 0.001) and overall complication rates (23.6% vs. 19.7%; p < 0.001) were significantly greater in the diabetes group, driven mainly by cardiac events (16.8% vs. 10.5%; p < 0.001). Multivariable logistic regression confirmed diabetes as an independent predictor of in-hospital mortality (odds ratio, 1.99; 95% confidence interval, 1.60-2.47; p < 0.001).

conclusionsDiabetes was associated with higher in-hospital mortality and complication rates among patients with MASLD hospitalized for CVD. Stratification of MASLD by metabolic phenotype, particularly in the presence of diabetes, may help improve risk assessment and inform more personalized clinical management in this population.

Indexed as

Cardiovascular DiseasesDiabetes MellitusFatty LiverNon-alcoholic Fatty Liver DiseaseAgedCross-Sectional StudiesDatabases, FactualFemaleHospitalizationHospital MortalityHumansJapanMaleMiddle AgedRetrospective StudiesRisk Factorscardiovascular diseasediabetesin‐hospital mortalitymetabolic dysfunction‐associated steatotic liver disease

Identifiers

PMID41692976
PMCPMC13074152

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.