Evidence map›Paper›PMID 41692957›Full record

ArticleAutophagy2026

Phase separation of OPTN initiates mitophagy to orchestrate craniofacial bone mineralization.

Haojie Liu, Zhenyi Lu, Xinyu Zhang, Yan Wang, Xiao Ge, Simai Chen, Yumeng Shi, Jingjing Yan, Rongyao Xu, Junqing Ma and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Autophagy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Haojie LiuDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Zhenyi LuDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Xinyu ZhangDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Yan WangDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Xiao GeDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Simai ChenDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Yumeng ShiDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Jingjing YanDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Rongyao XuDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Junqing MaSavaid Stomatology School, Hangzhou Medical College, Hangzhou, China.
Shuyu GuoDepartment of Orthodontics, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, mitophagy-mediated bone mineralization of mesenchymal stem cells has emerged as another bone formation pattern, but whether mitophagy-mediated bone mineralization shapes craniofacial development remains unknown. Here, we demonstrate that loss of OPTN, a keystone macroautophagy/autophagy receptor, impairs mitophagy and acidic calcium phosphate (ACP) transport in orofacial bone mesenchymal stem cells (OMSCs), leading to craniofacial bone mineralization defects. We substantiate that OPTN undergoes LLPS both

Indexed as

Calcification, PhysiologicCell Cycle ProteinsFacial BonesMembrane Transport ProteinsMitophagySkullTranscription Factor TFIIIAAnimalsHumansMesenchymal Stem CellsMiceMitochondriaPhosphorylationZebrafishCell Cycle ProteinsMembrane Transport ProteinsOPTN protein, humanOptn protein, mouseTranscription Factor TFIIIABone mineralizationcraniofacial developmentmitophagyOPTNphase separation

Identifiers

PMID41692957
PMCPMC13097790

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.