Evidence map›Paper›PMID 41692682›Full record

ArticleJournal of sleep research2026

Sleep Improvement for Metabolic Health: A Feasibility Trial of a Digital Sleep Treatment in People With Insomnia and Non-Diabetic Hyperglycaemia.

Rachel Sharman, David Ray, Andrew Farmer, Poppy C E Green, Victoria Harris, Fredrik Karpe, Colin A Espie, Diana Mantripp, Thomas Marjot, Niall M McGowan and 2 more

Abstract read
In one paragraph

Article in Journal of sleep research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Rachel SharmanSir Jules Thorn Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-1683-0477
David RaySir Jules Thorn Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Andrew FarmerNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Poppy C E GreenSir Jules Thorn Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Victoria HarrisNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Fredrik KarpeOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Colin A EspieSir Jules Thorn Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.ORCID https://orcid.org/0000-0002-1294-8734
Diana MantrippOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Thomas MarjotOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Niall M McGowanSir Jules Thorn Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Jeremy W TomlinsonOxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
Simon D KyleSir Jules Thorn Sleep and Circadian Neuroscience Institute, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.

Funding

NIHR Oxford Biomedical Research Centre BRC-1215-20008NIHR Oxford Health Biomedical Research Centre NIHR203316
6 · The paper itself

Abstract

Insomnia may play a causal role in type 2 diabetes (T2D). Addressing insomnia through cognitive behavioural therapy (CBTi) in people with non-diabetic hyperglycaemia could potentially reduce the risk of progression to T2D. To inform a future randomised trial, we performed a feasibility study of digital CBT (dCBTi) in individuals at increased risk of T2D. Participants were identified from 10 primary care practices in the UK and given access to dCBTi. Outcomes were evaluated at baseline (Week-0) and post-treatment (Week-11). Primary feasibility outcomes were ability to recruit and treatment engagement. We also quantified within-group mean change (95% CI) in insomnia severity (Insomnia Severity Index), health-related quality of life (EQ-5D-3L), depression (Center for Epidemiologic Studies Depression Scale), chronotype (reduced Morningness-Eveningness Questionnaire), sleep (7-day actigraphy and diary), continuous glucose monitoring (7-days) and fasting blood metabolites (insulin, lipids, glucose and C-reactive protein). The recruitment target was 20. Of 242 people completing screening, 36 were eligible and 24 were enrolled (age 65.5 ± 12.4 years, 70.8% female). Twenty-three (96%) completed post-intervention assessments. Treatment engagement was excellent (83.3% completed ≥ 4 sessions). The intervention was associated with a large reduction in insomnia severity [-4.7 (95% CI: -6.2 to -3.2), d = -1.4] and medium reduction in depressive symptoms [-2.7 (95% CI: -5.1 to -0.2), d = -0.5]. Sleep diary parameters tended to show greater improvement following intervention relative to actigraphy. There was evidence of a reduction in serum lactate, glycerol and triglycerides but no clear change in glucose or insulin. Results suggest a full trial is likely feasible and that people with NDH find the intervention acceptable and beneficial. Trial Registration: This trial was prospectively registered on the UKs clinical study registry, the ISRCTN (ISRCTN19682964, https://doi.org/10.1186/ISRCTN19682964).

Indexed as

Cognitive Behavioral TherapyHyperglycemiaSleep Initiation and Maintenance DisordersActigraphyAgedChronotypeContinuous Glucose MonitoringDepressionDiabetes Mellitus, Type 2Digital HealthFeasibility StudiesFemaleHumansMaleMiddle AgedQuality of Lifedigital cognitive behavioural therapyinsomniametabolic dysfunctionnon‐diabetic hyperglycaemiapre‐diabetes

Identifiers

PMID41692682
PMCPMC13619033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.