ArticleThe Journal of veterinary medical science2026
A calcium-associated serum metabolomic fingerprint in anorectic dairy cows.
Article in The Journal of veterinary medical science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Anorexia in dairy cows arises from diverse causes, including metabolic disorders with and without hypocalcemia. We analyzed the serum metabolites of 21 clinical anorectic cows using two-dimensional gas chromatography coupled with mass spectrometry to determine if the serum metabolome varies across the continuum of total calcium (tCa) in anorectic cows. We tested associations between tCa and the 1,645 detected metabolites by using rank-based partial Spearman correlations, adjusting for age and days in milk. A composite fingerprint derived from the 24 metabolites traced tCa (ρ= -0.773, P=0.0004). A metabolomic fingerprint associated with serum calcium levels could provide new insights into the transition from threshold thinking to continuous exploratory physiology in dairy cows.
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