Evidence map›Paper›PMID 41692420›Full record

Observational studyJournal of glaucoma2026

The Incidence of Clinically Significant Hypotony After Trabeculectomy.

Daniela Khaliliyeh, Sangwook Jin, Esteban Morales, Alessandro Rabiolo, Agustina de Gainza, Brayden K Leyva, Joseph Caprioli

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Journal of glaucoma, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Daniela KhaliliyehGlaucoma Division, Jules Stein Eye Institute, University of California Los Angeles (UCLA), Los Angeles, CA.
Sangwook JinGlaucoma Division, Jules Stein Eye Institute, University of California Los Angeles (UCLA), Los Angeles, CA.
Esteban MoralesGlaucoma Division, Jules Stein Eye Institute, University of California Los Angeles (UCLA), Los Angeles, CA.
Alessandro RabioloDepartment of Ophthalmology, University Hospital Maggiore della Carita'.
Agustina de GainzaConsultores Oftalmológicos, Buenos Aires, Argentina.
Brayden K LeyvaGlaucoma Division, Jules Stein Eye Institute, University of California Los Angeles (UCLA), Los Angeles, CA.
Joseph CaprioliGlaucoma Division, Jules Stein Eye Institute, University of California Los Angeles (UCLA), Los Angeles, CA.

Funding

Payden Memorial, Simms/Mann Family
6 · The paper itself

Abstract

prcisThis is a retrospective observational study investigating the congruity between numerical and clinical hypotony and the risk factors for clinical manifestations of hypotony after trabeculectomy. PURPOSE: To identify risk factors associated with clinically meaningful hypotony after trabeculectomy.

designRetrospective cohort study.

methodsPatients who underwent trabeculectomy with mitomycin-C (MMC) were included. Clinical hypotony was defined as the presence (≥ 3 wk after surgery) of choroidal detachment, hypotony keratopathy, hypotony maculopathy, or shallow anterior chamber or the need for trabeculectomy revision to resolve the hypotony at any time after surgery. Numerical hypotony was defined as intraocular pressure (IOP) ≤5 mmHg in 2 or more consecutive visits, at least one of them ≥ 3 weeks after surgery. Baseline, intraoperative, and postoperative characteristics were evaluated as potential risk factors. Univariable and multivariable analyses were conducted to assess the association between each characteristic and the presence of clinical hypotony.

resultsNine hundred ninety-two eyes were included. Two hundred eighty-four eyes (28.6%) met the criteria for numerical hypotony, 222 of which (79.9%) did not show any clinical sequelae of hypotony. 99 eyes (10%) met our criteria for clinical hypotony, whereas 42 of them (42.4%) did not have numerical hypotony. The most frequent manifestation of hypotony was serous choroidal effusion (54 eyes, 5.4%) followed by shallow anterior chamber (28 eyes, 2.8%). Thirty-four eyes (3.4%) underwent trabeculectomy revision to treat the hypotony. Asian ethnicity mitigated against the development of clinical hypotony (OR: 0.29, CI: 0.10-0.72, P =0.015) and the requirement for suture lysis postoperatively was associated with a lower risk of clinical hypotony (OR: 0.49, CI: 0.29-0.81, P =0.006).

conclusionsA minority of eyes (20.1%) with numerical hypotony showed clinical manifestations of low IOP. Asian ethnicity and eyes that required suture lysis postoperatively tended to have less incidence of clinical sequelae of hypotony after trabeculectomy.

Indexed as

GlaucomaIntraocular PressureOcular HypotensionPostoperative ComplicationsTrabeculectomyAgedAged, 80 and overAlkylating AgentsFemaleHumansIncidenceMaleMiddle AgedMitomycinRetrospective StudiesRisk FactorsAlkylating AgentsMitomycinglaucomahypotonyrisk factorssurgerytrabeculectomy

Identifiers

PMID41692420
PMCPMC13015807

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.