Evidence map›Paper›PMID 41692274›Full record

ArticleContemporary clinical trials2026

Multilevel Action Toward Colorectal Cancer and Hepatitis C Education and Screening (MATCHES): Study protocol for a hybrid 1 stepped-wedge multibehavioral randomized trial.

Rania Abdulla, Carol Boxtha, Emily P Courtney, Oyedolapo A Anyanwu, Steven K Sutton, Katherine Chung-Bridges, Hirut G Kassaye, Elizabeth Philippe, Kelly A Mudon, Estefany Frias and 10 more

Registry-linked trialAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Contemporary clinical trials, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06745895 (Multilevel Action Toward Colorectal Cancer and Hepatitis C Education and Screening), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06745895 narecruitingnot on this map

Multilevel Action Toward Colorectal Cancer and Hepatitis C Education and Screening (MATCHES)

TypeinterventionalSponsorH. Lee Moffitt Cancer Center and Research InstituteRan2024 to 2028Enrolled350ConditionsColorectal Cancer Screening, Hepatitis C VirusArmsMATCHES
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Rania AbdullaNon-Therapeutic Research Office, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA. Electronic address: Rania.Abdulla@moffitt.org.
Carol BoxthaNon-Therapeutic Research Office, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA. Electronic address: Carol.Boxtha@moffitt.org.
Emily P CourtneyDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA. Electronic address: Emily.Courtney@moffitt.org.
Oyedolapo A AnyanwuDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA. Electronic address: Dolapo.Anyanwu@moffitt.org.
Steven K SuttonDepartment of Biostatistics and Bioinformatics, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA; Morsani College of Medicine, University of South Florida, 560 Channelside Dr, Tampa, FL, USA. Electronic address: Steve.Sutton@moffitt.org.
Katherine Chung-BridgesHealth Choice Network, 9064 NW 13th Terrace, Miami, FL, USA. Electronic address: KChung@hcnetwork.org.
Hirut G KassayeHealth Choice Network, 9064 NW 13th Terrace, Miami, FL, USA. Electronic address: hkassaye@hcnetwork.org.
Elizabeth PhilippeCommunity Health of South Florida, Inc., 10300 SW 216th Street, Miami, FL, USA. Electronic address: EPhilippe@chisouthfl.org.
Kelly A MudonCommunity Health of South Florida, Inc., 10300 SW 216th Street, Miami, FL, USA. Electronic address: KAMudon@chisouthfl.org.
Estefany FriasFormerly with Community Health of South Florida, Inc., 10300 SW 216th Street, Miami, FL, USA.
Daniel ParrasFormerly with Health Choice Network, 9064 NW 13th Terrace, Miami, FL, USA.
Natasha AvrilienHealth Choice Network, 9064 NW 13th Terrace, Miami, FL, USA. Electronic address: NAvrilien@HCNetwork.org.
Mark FriedmanMorsani College of Medicine, University of South Florida, 560 Channelside Dr, Tampa, FL, USA; Department of Gastrointestinal Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA. Electronic address: Mark.Friedman@moffitt.org.
Kea TurnerDivision of Health Systems, Policy, and Innovation, School of Nursing, University of North Carolina at Chapel Hill, 104 Airport Drive, Chapel Hill, NC, USA; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, 101 Manning Drive, Chapel Hill, NC, USA. Electronic address: Kea.Turner@unc.edu.
Gloria D CoronadoDepartment of Population Science, University of Arizona Cancer Center, 1515 N Campbell Avenue, Tuscon, AZ, USA. Electronic address: gdcoronado@arizona.edu.
Victoria L ChampionSchool of Nursing, Indiana University, 600 Barnhill Dr., Indianapolis, IN, USA; Indiana University Simon Comprehensive Cancer Center, Indianapolis, IN, USA. Electronic address: vchampio@iu.edu.
Jonathan N TobinClinical Directors Network (CDN), New York, USA; Center for Clinical and Translational Science, The Rockefeller University, 1230 York Ave, NY, New York, USA. Electronic address: jntobin@CDNetwork.org.
Susan T VadaparampilDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA; Morsani College of Medicine, University of South Florida, 560 Channelside Dr, Tampa, FL, USA; Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA. Electronic address: Susan.Vadaparampil@moffitt.org.
Clement K GwedeDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA; Morsani College of Medicine, University of South Florida, 560 Channelside Dr, Tampa, FL, USA; Department of Gastrointestinal Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA. Electronic address: Clement.Gwede@moffitt.org.
Shannon M ChristyDepartment of Health Outcomes and Behavior, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA; Morsani College of Medicine, University of South Florida, 560 Channelside Dr, Tampa, FL, USA; Department of Gastrointestinal Oncology, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA; Center for Immunization and Infection Research in Cancer, Moffitt Cancer Center, 12902 Magnolia Drive, Tampa, FL, USA. Electronic address: Shannon.Christy@moffitt.org.

Funding

TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI John L. Cleveland · 1998 to 2026
$93.5M
Behavioral Oncology Education & Career DevelopmentT32CA090314 · NCI · H. LEE MOFFITT CANCER CTR & RES INST · PI Vani N Simmons, SUSAN T VADAPARAMPIL · 2019 to 2026
$2.9M
NCI NIH HHS P30 CA076292NCI NIH HHS T32 CA090314
6 · The paper itself

Abstract

backgroundThe current paper describes the protocol for the Hybrid type 1 effectiveness-implementation trial titled Multilevel Action Toward Colorectal Cancer and Hepatitis C Education and Screening (MATCHES). The aims of the MATCHES intervention trial are to promote both colorectal cancer (CRC) and hepatitis C virus (HCV) screening among patients aged 45-75 years old receiving primary care at a federally qualified health center (FQHC) who are not currently up-to-date with both screenings and to examine implementation outcomes.

methodsTen health center sites in the FQHC will be randomized in two waves using a stepped wedge design. Intervention strategies target the system, clinician, and patient levels. System-level strategies include a customized electronic health record best practice alert that pairs CRC and HCV screening and standard operating procedures. Clinician-level strategies include a training session and feedback on screening rates. Patient-level strategies include a theory-informed educational booklet about CRC and HCV screening in English or Spanish and access to stool DNA testing and HCV screening among 350 participants. The primary outcome is both CRC and HCV screening uptake at 12 months post-intervention among 350 participants. System-wide CRC and HCV screening rates among patients 45-75 years old also will be monitored. Implementation barriers and facilitators will be examined.

resultsThe project is ongoing; effectiveness and implementation outcomes will be determined following study completion.

conclusionsResults may inform potential subsequent scale-up and offer insights for promoting multiple screening behaviors in a single intervention. CLINICAL TRIALS IDENTIFIER: NCT06745895 (date registered: 2024-12-20); https://clinicaltrials.gov/study/NCT06745895?cond=CRC%20AND%20HCV&rank=.

Indexed as

Colorectal NeoplasmsEarly Detection of CancerHepatitis CMass ScreeningPatient Education as TopicAgedFemaleHumansMaleMiddle AgedMulticenter Studies as TopicPrimary Health CareRandomized Controlled Trials as TopicColorectal cancer screeningHepatitis C virus screeningHybrid implementation-effectiveness trialMultilevel interventionRandomized trialStudy protocol

Identifiers

PMID41692274
PMCPMC13094859

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.