Evidence map›Paper›PMID 41691915›Full record

ArticlePsychiatry research. Neuroimaging2026

Alcohol misuse and negative emotion processing in neurotypical drinkers: Sex differences in behavioral and neural markers.

Shefali Chaudhary, Yu Chen, Hak Kei Wong, Herta H Chao, Chiang-Shan R Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Psychiatry research. Neuroimaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shefali ChaudharyDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Yu ChenDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Hak Kei WongUniversity College London, London, UK.
Herta H ChaoDepartment of Medicine, VA Connecticut Healthcare System, West Haven, CT, USA; Department of Medicine, Yale University School of Medicine, New Haven, CT, USA.
Chiang-Shan R LiDepartment of Psychiatry, Yale University School of Medicine, New Haven, CT, USA; Department of Neuroscience, Yale University School of Medicine, New Haven, CT, USA; Wu Tsai Institute, Yale University, New Haven, CT, USA. Electronic address: chiang-shan.li@yale.edu.

Funding

Neurocognitive Changes from Long-Term Androgen Deprivation Therapy in Prostate Cancer PatientsR01CA218501 · NCI · YALE UNIVERSITY · PI CHAO, HERTA HUEY-AN · 2018 to 2023
$1.9M
Noradrenergic mechanisms of alcohol's impact on the development of MCI and early stage ADR01AG072893 · NIA · YALE UNIVERSITY · PI LI, CHIANG-SHAN RAY · 2020 to 2024
$1.8M
Multi-level statistical classification of substance use disorderR01DA051922 · NIDA · UNIVERSITY OF CONNECTICUT STORRS · PI BI, JINBO, LI, CHIANG-SHAN RAY · 2020 to 2023
$1.8M
Emotion network dysfunction and anxiety in early Alzheimer's diseaseK99AG088064 · NIA · YALE UNIVERSITY · PI Shefali Chaudhary · 2025 to 2026
$266k
CSRD VA I01 CX001301NCI NIH HHS R01 CA218501NIA NIH HHS K99 AG088064NIA NIH HHS R01 AG072893NIDA NIH HHS R01 DA051922
6 · The paper itself

Abstract

Negative emotion contributes to problem drinking. Men and women may differ in the mechanisms of negative emotion processing and the pathophysiology of alcohol misuse. However, few have investigated sex differences in the impact of alcohol misuse on negative emotion processing. We addressed this issue in a community sample of 148 drinkers (71 women) evaluated with Alcohol Use Disorder Identification Test (AUDIT; men/women 4.4 ± 5.4/4.2 ± 5.6, mean±SD) and functional imaging in a Hariri task. Men and women did not differ in reaction time (RT

Indexed as

AlcoholismBrainEmotionsSex CharacteristicsAdultAlcohol DrinkingBrain MappingFemaleHumansMagnetic Resonance ImagingMaleReaction TimeYoung AdultAlcohol misuseAnxietyEmotionfMRIHaririReaction time

Identifiers

PMID41691915
PMCPMC12990894

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.