Evidence map›Paper›PMID 41691824›Full record

ArticleDrug and alcohol dependence2026

Sleep disturbance is associated with greater subjective and neural negative emotionality in people with alcohol use disorder.

Erica N Grodin, Dylan E Kirsch, Wave Ananda Baskerville, Lara A Ray

Abstract read
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In one paragraph

Article in Drug and alcohol dependence, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Erica N GrodinDepartment of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA, United States; Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, United States.
Dylan E KirschDepartment of Psychology, University of California at Los Angeles, Los Angeles, CA, United States.
Wave Ananda BaskervilleDepartment of Psychology, University of California at Los Angeles, Los Angeles, CA, United States.
Lara A RayDepartment of Psychiatry and Biobehavioral Sciences, University of California at Los Angeles, Los Angeles, CA, United States; Brain Research Institute, University of California at Los Angeles, Los Angeles, CA, United States; Department of Psychology, University of California at Los Angeles, Los Angeles, CA, United States. Electronic address: lararay@psych.ucla.edu.

Funding

A Randomized Controlled Clinical Trial of the Neuroimmune Modulator Ibudilast for the Treatment of Alcohol Use DisorderR01AA026190 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RAY, LARA A. · 2018 to 2021
$2.7M
Clinical Neuroscience of Alcoholism: Integrating Neuroscience and Clinical TrialsK24AA025704 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LARA A. RAY · 2018 to 2026
$1.3M
Characterizing the Microbiome-Gut-Brain Axis in Individuals with Alcohol Use DisorderK01AA029712 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Erica N Grodin · 2022 to 2026
$819k
Testing Neurobiological Models of Alcohol Use Disorder Through Real World Cue Reactivity and MoodF31AA031914 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BASKERVILLE, WAVE-ANANDA · 2024 to 2025
$83k
A clinical neuroscience approach to understand stress coping in alcohol use disorderF32AA031425 · NIAAA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI KIRSCH, DYLAN E · 2024 to 2024
$32k
NIAAA NIH HHS F31 AA031914NIAAA NIH HHS F32 AA031425NIAAA NIH HHS K01 AA029712NIAAA NIH HHS K24 AA025704NIAAA NIH HHS R01 AA026190
6 · The paper itself

Abstract

backgroundSleep disturbance is ubiquitous in alcohol use disorder (AUD). Sleep disturbance within AUD has been mapped onto the three-stage addiction cycle. The Addictions Neuroclinical Assessment (ANA) is a neuroscience-based framework, which measures functional domains that correspond to the stages of the addiction cycle. The present study investigated the relationship between sleep disturbance and AUD neuroclinical phenomenology and underlying neurobiology.

methodsIn two independent studies, participants completed assessments of sleep disturbance through the Pittsburgh Sleep Quality Index (PSQI; n = 115) or the Insomnia Severity Index (ISI; n = 102). A subset of individuals (n = 52) completed a functional magnetic resonance imaging scan to assess the neurobiology of the incentive salience and negative emotionality domains.

resultsBoth studies found that sleep disturbance was associated with negative emotionality (ps≤0.001), but not incentive salience (ps>0.14) or executive function (p = 0.62). Individuals with sleep disturbance had greater activation in the frontal pole, anterior cingulate, medial frontal cortex, and posterior cingulate cortex when viewing negative vs. neutral images, compared to those without sleep disturbance, indicating an underlying neural substrate for the heightened negative emotionality neuroclinical profile.

conclusionsThese results suggest that sleep disturbances in AUD are associated with a neurofunctional profile of enhanced negative emotionality and identify a potential neurobiology underlying this association. These findings suggest that sleep disturbance may be a promising treatment target to improve negative emotionality in this group.

Indexed as

AlcoholismBrainEmotionsSleep Wake DisordersAdultFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedAddictions neuroclinical assessmentAlcohol use disorderInsomniaNegative emotionalitySleep disturbance

Identifiers

PMID41691824
PMCPMC13094390

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.