ArticleCurrent medical imaging2026
Intratumoral and Peritumoral Radiomics based on Contrast-enhanced CT Images: Biomarkers to Predict the Risk-Grade of Gastrointestinal Stromal Tumors
Article in Current medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionThis study aimed to investigate the value of intratumoral and peritumoral radiomics in predicting the risk grade of gastrointestinal stromal tumors (GISTs) using contrast-enhanced computed tomography (CT) images.
methodsA total of 217 pathology-confirmed GISTs were retrospectively enrolled and divided into low-risk and high-risk groups. Significant predictors were selected from clinical and radiological characteristics to build a prediction model. Radiomics features were extracted from the intratumoral region, the 3-mm peritumoral region, and the 5-mm peritumoral region. After ANOVA and LASSO feature screening, logistic regression was applied to construct the radiomics model. The Rad-score of the optimal radiomics model was calculated and combined with the selected radiological characteristics to develop a combined model and a nomogram. ROC curves were used to assess the predictive performance of each model, while calibration curves and decision curve analysis were used to evaluate their clinical utility. The SHapley Additive Explanations (SHAP) method was applied to perform interpretability analysis of the optimal model.
resultsA radiological model (RM), five radiomics models, and a combined radiological characteristics plus Rad-score model (CRM) were constructed. In the validation set, the AUCs of the RM and CRM were 0.839 and 0.924, respectively. The intratumoral plus 3-mm peritumoral radiomics model (ITV+PTV3) achieved the best performance in the validation set, with an AUC of 0.934. DISCUSSION: The ITV+PTV3 model shows strong potential for objective GIST risk stratification but requires multi-center prospective validation to ensure generalizability beyond the limitations of this retrospective dataset.
conclusionRadiomics models based on intratumoral and peritumoral regions perform well in predicting the risk grade of GISTs and may effectively guide accurate preoperative diagnosis and treatment planning.
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