Evidence map›Paper›PMID 41691595›Full record

ArticleExperimental physiology2026

Pulmonary arterial mechanoreceptors mediate sustained sympathoexcitation during high altitude hypoxia in humans.

Michiel T Ewalts, Lydia L Simpson, Jack S Talbot, Elliott J Jenkins, Travis D Gibbons, Connor A Howe, Lauren E Maier, Emily R Vanden Berg, Alex M Williams, Philip N Ainslie and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Michiel T EwaltsInstitute for Applied Human Physiology, Department of Sport and Exercise Sciences, College of Medicine and Health, Bangor University, Bangor, UK.
Lydia L SimpsonBristol Medical School, University of Bristol, Bristol, UK.
Jack S TalbotCardiometabolic Health and Exercise Physiology Laboratory, Baker Heart and Diabetes Institute, Melbourne, Australia.
Elliott J JenkinsCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.
Travis D GibbonsCentre for Heart, Lung, and Vascular Health, University of British Columbia Okanagan, Kelowna, Canada.
Connor A HoweDepartment of Sport Science, Performance Physiology and Prevention, Universität Innsbruck, Innsbruck, Austria.
Lauren E MaierCentre for Heart, Lung, and Vascular Health, University of British Columbia Okanagan, Kelowna, Canada.
Emily R Vanden BergNeurovascular Health Laboratory, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Canada.
Alex M WilliamsDepartment of Cellular and Physiological Sciences, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Philip N AinslieCentre for Heart, Lung, and Vascular Health, University of British Columbia Okanagan, Kelowna, Canada.
Samuel J OliverInstitute for Applied Human Physiology, Department of Sport and Exercise Sciences, College of Medicine and Health, Bangor University, Bangor, UK.ORCID https://orcid.org/0000-0002-9971-9546
Craig D SteinbackNeurovascular Health Laboratory, Faculty of Kinesiology, Sport, and Recreation, University of Alberta, Canada.
Mike StembridgeCardiff School of Sport and Health Sciences, Cardiff Metropolitan University, Cardiff, UK.ORCID https://orcid.org/0000-0003-0818-6420
Jonathan P MooreInstitute for Applied Human Physiology, Department of Sport and Exercise Sciences, College of Medicine and Health, Bangor University, Bangor, UK.ORCID https://orcid.org/0000-0002-4244-8220

Funding

Bangor UniversityCardiff Metropolitan UniversityHCRW_Llywodraeth Cymru BHF-NCRNNatural Sciences and Engineering Research Council of Canada RGPINNatural Sciences and Engineering Research Council of Canada RGPIN-2020-05385
6 · The paper itself

Abstract

Sympathetic nervous system activation is a hallmark of high-altitude hypoxia, yet the afferent mechanisms remain incompletely defined. We examined the relative contributions of pulmonary arterial mechanoreceptors and carotid chemoreceptors - two excitatory pathways co-activated by hypoxia - to sustained sympathoexcitation at altitude. Nine healthy lowlanders (27 ±  7 years, three female) were studied after 6-9 days at 3800 m under four conditions: (1) control, (2) inhaled nitric oxide (iNO, 40 ppm) to reduce pulmonary arterial pressure, (3) low-dose dopamine infusion (2 µg kg

Indexed as

cardiovascular controlexercisemicroneurographyMSNAsympathetic activation

Identifiers

PMID41691595
PMCPMC13394917

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.