ArticleVirchows Archiv : an international journal of pathology2026
Pilocytic astrocytoma in pediatric and adult patients: a single-center analysis of 650 cases.
Article in Virchows Archiv : an international journal of pathology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
This retrospective study of 650 Chinese Pilocytic astrocytoma (PA) patients aimed to define age-related distinctions and prognostic factors. Demographic, imaging, histopathological, and genetic data were analyzed. Pediatric PAs more commonly arose in the posterior fossa and exhibited larger size, exuberant vasculopathy, pilomyxoid features, brisk mitotic activity, and dispersed histological patterns. In contrast, adult PAs were more frequently supratentorial and demonstrated higher rates of calcification, hemosiderin, necrosis, inflammation, and compact patterns. Molecularly, pediatric patients harbored more frequent BRAF translocations, while BRAF V600E mutations and non-BRAF alterations were more common in adults. Among 564 patients (86.8%) with a median follow-up duration of 60 months (range, 2-182 months). Tumor progression occurred in 79 patients (14.0%), and 16 patients (2.8%) died. Kaplan-Meier analysis showed that tumors located in the optic pathway/midline and spinal cord, along with certain histological features (such as lack of calcification and hemosiderin, presence of pilomyxoid changes, exuberant vasculopathy, and brisk mitoses), had significantly poorer outcomes. BRAF alterations predicted more favorable progression-free survival (PFS). Patients undergoing gross-total or near-total resection (GTR/NTR) had superior outcomes, and unexpectedly, those with partial resection had shorter PFS than those with biopsy alone. Multivariable Cox regression confirmed GTR/NTR and low mitotic activity as independent predictors of improved PFS. No significant survival differences were observed by age group. Pediatric and adult PAs differ in histopathology and BRAF alterations, suggesting different prognosis. GTR/NTR and low mitotic activity independently predict improved PFS, highlighting the need for integrated diagnostic approaches.
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