Evidence map›Paper›PMID 41691486›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

UBE2T-Driven p53 Degradation Rewires Glycolysis to Orchestrate Lactylation-Mediated CAFs Activation and ECM Deposition in Pancreatic Cancer.

Yong Ma, Wenbo Liu, Mingdou Li, Tao Wang, Bin Zhao, Keshen Wang, Qichen He, Haonan Sun, Huiguo Qing, Xiaoying Guan and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yong MaThe Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.ORCID https://orcid.org/0000-0001-5323-9320
Wenbo LiuThe Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.ORCID https://orcid.org/0009-0006-0462-4808
Mingdou LiThe Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.ORCID https://orcid.org/0009-0007-2774-6565
Tao WangThe Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Bin ZhaoThe Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Keshen WangDepartment of Neurosurgery, Lanzhou University Second Hospital, Lanzhou, China.
Qichen HeThe Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Haonan SunThe Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Huiguo QingThe Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Xiaoying GuanDepartment of Pathology, Lanzhou University Second Hospital, Lanzhou, China.
Wengui ShiGansu Tumor Immunology Basic Disciplines Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Long QinGansu Tumor Immunology Basic Disciplines Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Yuman DongGansu Tumor Immunology Basic Disciplines Research Center, The Second Hospital & Clinical Medical School, Lanzhou University, Lanzhou, China.
Huinian ZhouDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou, China.
Zeyuan YuDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou, China.ORCID https://orcid.org/0000-0002-7814-5416
Xiangyan JiangDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou, China.ORCID https://orcid.org/0000-0002-2685-2899
Zuoyi JiaoDepartment of General Surgery, Lanzhou University Second Hospital, Lanzhou, China.ORCID https://orcid.org/0000-0003-1942-0905

Funding

Gansu Province Joint Scientific Research Fund 24JRRA920toZ.-Y.J.Gansu Province Traditional Chinese Medicine Science and Technology Tackling Key Projects GZKZ-2024-23 to Z.-Y. JGansu Provincial Health Industry Science and Technology Innovation Major Scientific Research Project GSWSZD2024-14 to Z.-Y. JLanzhou University Second Hospital 2025-24-zdfy-021toY.M.CY2022-ZD-01toZ.-Y.JNational Natural Science Foundation of China 82473377 to Z.-Y. J.824B2080 to Y. M.823B2073 to X.-Y. J.82160487 to Z.-Y.Y.
6 · The paper itself

Abstract

Although glycolysis is a metabolic hallmark of pancreatic ductal adenocarcinoma (PDAC), it remains unclear whether the excessive lactate produced regulates CAF lactylation to promote extracellular matrix (ECM) deposition. The multi-omics and spontaneous model findings indicate that lactate accumulation in the tumor microenvironment (TME) promotes histone H3 lysine 18 lactylation (H3K18la) and activation of cancer-associated fibroblasts (CAFs), leading to both ECM densification and impaired immunotherapy efficacy in PDAC. Mechanistically, ubiquitin-conjugating enzyme E2T (UBE2T) acts as an initiating factor that promotes p53 positive feedback degradation through modulation of ribosome biogenesis, thereby enhancing lactate metabolic crosstalk via glycolytic reprogramming. Genetic ablation or pharmacological inhibition of UBE2T using the selective inhibitor pentagalloylglucose (PGG) disrupts lactate metabolic crosstalk, suppresses stromal deposition, and promotes intratumoral CD8

Indexed as

Cancer-Associated FibroblastsCarcinoma, Pancreatic DuctalExtracellular MatrixGlycolysisPancreatic NeoplasmsTumor Suppressor Protein p53Ubiquitin-Conjugating EnzymesAnimalsCell Line, TumorHumansMetabolic ReprogrammingMiceTumor MicroenvironmentTumor Suppressor Protein p53Ubiquitin-Conjugating Enzymesimmunotherapylactylationpancreatic cancertumor microenvironmentUBE2T

Identifiers

PMID41691486
PMCPMC13088301

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.