Evidence map›Paper›PMID 41691483›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Neutrophil-Mimetic Nanoscavengers Target the Inflammatory Microenvironment to Eliminate NETs/ROS and Immunomodulate cGAS-STING Signaling in Septic AKI.

Zening Zhang, Chenxi Zhang, Ranran Luo, Qiuchi Wu, Pengchen Ren, Xinyu Liu, Yingying Luo, Zhongsheng Xu, Xiaojing He, Yun Liu

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zening ZhangDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Chenxi ZhangDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ranran LuoDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Qiuchi WuDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Pengchen RenDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Xinyu LiuDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yingying LuoDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Zhongsheng XuDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0002-3234-2115
Xiaojing HeDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Yun LiuDepartment of Radiology, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.ORCID https://orcid.org/0000-0001-7761-309X

Funding

Chongqing Returned Overseas Students' Entrepreneurship and Innovation Support Program cx2021006CQMU Program for Youth Innovation in Future Medicine W0171Kuanren Doctoral Supervisor Cultivation Program and Kuanren Talents Program of the Second Affiliated Hospital of CQMUKuanren Talent Reserve Program for Academic&Technical Leadership 2025-53Natural Science Foundation of Chongqing CSTB2024NSCQ-MSX0394Senior Medical Talents Program of Chongqing for Young and Middle-aged
6 · The paper itself

Abstract

Sepsis-associated acute kidney injury (SAKI) remains a life-threatening condition with limited therapeutic options, primarily driven by rampant oxidative stress, inflammatory dysregulation. Importantly, aberrant formation of neutrophil extracellular traps (NETs) and sustained innate immune activation further exacerbate renal injury, highlighting the need for strategies that precisely modulate these intertwined pathological mechanisms. Here, we present neutrophil-mimetic nanoscavengers (MD@NM) that comprise a catalytic core of DNase-1-loaded Mn

Indexed as

Acute Kidney InjuryExtracellular TrapsInflammationNeutrophilsNucleotidyltransferasesReactive Oxygen SpeciesSepsisAnimalscGAS-STING Signaling PathwayCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseDisease Models, AnimalHumansMaleMembrane ProteinsMiceSignal TransductioncGAS protein, mouseCyclic Guanosine Monophosphate-Adenosine Monophosphate SynthaseMembrane ProteinsNucleotidyltransferasesReactive Oxygen SpeciesSTING ProteincGAS‐STING inhibitionnanoscavengerNETs degradationROS scavengingseptic acute kidney injury

Identifiers

PMID41691483
PMCPMC13104083

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.