Trial reportThe journals of gerontology. Series B, Psychological sciences and social sciences2026
Sex as a moderator of the association between cardiorespiratory fitness and depressive symptoms in older adults.
Trial report in The journals of gerontology. Series B, Psychological sciences and social sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02875301 (Investigating Gains in Neurocognition in an Intervention Trial of Exercise), which is not on this map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Gains in Neurocognition in an Intervention Trial of Exercise
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors.
Funding
Abstract
objectivesThe study investigates sex differences in how cardiorespiratory fitness (CRF) and accelerometry-based physical activity (PA) relate to depressive symptoms in community-dwelling older adults. We hypothesized that the relationship between higher CRF and PA levels with lower depressive symptoms would be more prominent in women relative to men.
methodsParticipants included 648 community-dwelling adults aged 65-80 (71% women [n = 461]; mean age [SD] = 69.88 [3.75]) without evidence of clinical depression (Geriatric Depression Scale score <9). CRF was assessed using a graded exercise test, and PA (light PA, moderate-to-vigorous PA [MVPA]) was assessed using a 7-day actigraphy protocol. Subsyndromal depressive symptoms were evaluated using the Hospital Anxiety and Depression Scale. Multiple linear regression analyses were performed to examine the relationships between CRF, light PA, MVPA, and depressive symptoms, adjusting for age, sex, years of education, body mass index, and anxiety symptoms, and to evaluate the moderating role of sex.
resultsHigher CRF and greater amounts of MVPA and light PA were associated with fewer depressive symptoms (β = -0.12, p = .010; β = -0.09, p = .021; and β = -0.13, p < .001, respectively) within the overall sample. However, moderation analysis by sex revealed that higher CRF was associated with fewer depressive symptoms only among female participants (β = -0.19, p < .001). Sex moderation effects were not observed for light PA or MVPA. DISCUSSION: These findings suggest CRF is a key physiological correlate of subsyndromal depressive symptoms in late life, particularly for women. Understanding sex-specific responses to PA may inform tailored prevention and intervention strategies targeting mood symptoms prior to full clinical expression of depression. CLINICAL TRIAL REGISTRATION NUMBER: NCT02875301.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.