ArticleBiophysical journal2026
Spatial relationships between vinculin tension and actin at cell adhesions define cell colony positioning and identity.
Article in Biophysical journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
The protein vinculin mediates actin-myosin-dependent adhesion strength to regulate force transmission at cellular adhesions. The precise distribution of forces sensed by vinculin that regulates downstream cellular processes remains unclear. To determine vinculin tension in multiple cell types, a FRET-based tension-sensitive module was knocked into the vinculin locus of human induced pluripotent stem cells. Measurements of vinculin tension and adhesion spatial distributions were used to create mechanical profiles that identify cellular origin and differentially correlate to cell shape characteristics. In stem cell colonies, edge cell morphology depended on high vinculin tension in basal adhesions connected to actin. These mechanical signatures were able to determine progression toward cardiomyocyte versus neural lineage commitment. Our findings suggest that spatial mapping of vinculin tension can define mechanical profiles that differentially correlate to cell morphologies that affect cell function and lineage fate.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.