ArticleBMC chemistry2026
Impact of chaotropic salts on separation simplification on liquid chromatographic determination of cisplatin, pheniramine and their related compound.
Article in BMC chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
In this work, we present the beneficial roles of chaotropic agents (salts) in the development of fast, simple, and cost-effective reversed-phase high-performance liquid chromatography with a Diode Array detector. Inclusion of the presence of strong chaotropic salts in mobile phase in their liquid chromatography determinations showed significant simplifications and shortening of run time of analysis. The roles of the two strongest chaotropic agents, salts, potassium hexafluorophosphate and sodium perchlorate in two different and independent research cases of two molecules of active pharmaceutical ingredients, cisplatin and pheniramine maleate, each with its specific related compounds and their pharmaceutical dosage forms, confirmed their highly applicable presence and usability in drug analytical method development. Two separate experiments, using different variable sets, were successfully conducted and presented, one with the strongest chaotropic anion -PF
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