Evidence map›Paper›PMID 41691322›Full record

ArticleCritical care (London, England)2026

Centralization of post-resuscitation care after out-of-hospital cardiac arrest at cardiac arrest centres: a Danish nationwide follow-up study.

Sivagowry Rasalingam Mørk, Emilie Gregers, Kristian Kragholm, Jesper Kjaergaard, Fredrik Folke, Christian Torp-Pedersen, Lars Køber, Anne Merete Boas Soja, Thomas Gerds, Felix Michalik and 6 more

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In one paragraph

Article in Critical care (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Sivagowry Rasalingam MørkDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Emilie GregersDepartment of Cardiothoracic Surgery, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Kristian KragholmDepartment of Cardiology, Aalborg University Hospital, Aalborg, Denmark.
Jesper KjaergaardDepartment of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Fredrik FolkeDepartment of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
Christian Torp-PedersenDepartment of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Lars KøberDepartment of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Anne Merete Boas SojaDepartment of Internal Medicine 1, Section of Cardiology, Regional Hospital, Holbæk, Denmark.
Thomas GerdsDepartment of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
Felix MichalikDepartment of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
Jacob Eifer MøllerDepartment of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Finn Lund HenriksenDepartment of Cardiology, Odense University Hospital, Odense, Denmark.
Freddy LippertEmergency Medical Services, Capital Region, Copenhagen, Denmark.
Christian Juhl TerkelsenDepartment of Cardiology, Aarhus University Hospital, Aarhus, Denmark.
Christian HassagerDepartment of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark.
Helle SøholmDepartment of Cardiology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark. helle.soholm@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundRecent guidelines recommend centralization of post-resuscitation care in out-of-hospital cardiac arrest (OHCA)-patients. Centralization has been gradually implemented in Denmark since 2009; however, no evaluation of centralization has yet been made. This study assesses the 30-day mortality before and after centralization, and the impact of centralization on survival in Denmark.

methodsThis nationwide study included consecutive adult OHCA patients with presumed cardiac cause admitted to a hospital. Centralization was introduced in 2009, 2011, and 2012 in four out of five regions. Temporal trends of 30-day mortality were evaluated in patients who were directly transported to CACs and in patients who were transported to non-CACs. A difference-in-difference model with repeated cross-sections was used to estimate the effect of centralization on the 30-day mortality between 2007 and 2020. The model was adjusted for additive effects of known covariates.

resultsA total of 14,276 patients were included. The majority of patients were aged between 50 to 75 years (57%) and 71% were male. From 2007 to 2020, the risk of 30-day mortality was reduced from 66 to 47% among patients transported to CACs and from 92 to 74% in patients transported to non-CACs. Centralization was significantly associated with an absolute risk reduction in mortality of 7% (95% CI: 2%-11%).

conclusionsIn this study, a mortality decline was observed for patients transported to CACs and non-CACs. Centralization was associated with a significant reduction of the absolute 30-day mortality risk of 7% after accounting for regional differences, time-trends in patients, and OHCA characteristics.

Indexed as

Out-of-Hospital Cardiac ArrestAgedCardiopulmonary ResuscitationDenmarkFemaleFollow-Up StudiesHumansMaleMiddle AgedRegistriesAcute cardiac careCentralizationOut-of-hospital cardiac arrestPost-resuscitation carePre-hospitalSurvival

Identifiers

PMID41691322
PMCPMC13041502

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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.