ArticleJournal of medical case reports2026
Naproxen as a cause of acute cholestatic hepatitis: a case report.
Article in Journal of medical case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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7 authors.
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Abstract
backgroundDrug-induced liver injury is a common cause of acute liver injury and acute liver failure worldwide, and nonsteroidal antiinflammatory drugs are the third most common pharmaceutical group related with its development. Between nonsteroidal antiinflammatory drugs, naproxen is a propionic derivate widely used and generally safe drug. CASE PRESENTATION: We present an 83 year-old Caucasian male patient with cholestatic acute liver injury secondary to naproxen with associated cholemic nephropathy and atrioventricular block during admission. The patient was managed with one session of plasma exchange, forced diuresis, ursodeoxycholic acid, and a short course of corticosteroids.
conclusionGiven the rarity of this phenomenon, we report this case to support the limited evidence available, particularly in the light of the widespread and routine utilization of nonsteroidal antiinflammatory drugs by a significant proportion of the population.
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