Antibiofilm compounds from Streptomyces Labedae 20PM improves survival of and prophylactic effect of Nile tilapia (Oreochromis niloticus) challenged with Aeromonas hydrophila.

Dinamella Wahjuningrum, Gisela Ignacia Tjandra, Afina Mauliana, Herlin Herlambang, Muhamad Gustilatov, Diana Elizabeth Waturangi

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Article in BMC research notes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Dinamella WahjuningrumDepartment of Aquaculture, IPB University, Dramaga Street, Bogor, 16680, Indonesia.

Gisela Ignacia TjandraDepartment of Biotechnology, Atma Jaya Catholic University of Indonesia, Jenderal Sudirman 51 Street, South Jakart, DKI Jakarta, 12930, Indonesia.

Afina MaulianaDepartment of Aquaculture, IPB University, Dramaga Street, Bogor, 16680, Indonesia.

Herlin HerlambangDepartment of Aquaculture, IPB University, Dramaga Street, Bogor, 16680, Indonesia.

Muhamad GustilatovDepartment of Aquaculture, IPB University, Dramaga Street, Bogor, 16680, Indonesia.

Diana Elizabeth WaturangiDepartment of Biotechnology, Atma Jaya Catholic University of Indonesia, Jenderal Sudirman 51 Street, South Jakart, DKI Jakarta, 12930, Indonesia. diana.waturangi@atmajaya.ac.id.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAeromonas hydrophila, a pathogen of concern in aquaculture, utilizes quorum sensing mechanism to form biofilms that significantly increase the risk of infection in aquaculture commodity such as Nile tilapia (Oreochromis niloticus). The biofilm structure produced by A. hydrophila not only enhances its resistance to antibiotics but also complicates treatment efforts.

resultsIn this study, we investigated the anti-quorum-sensing and biofilm disruption activities of bacterial extracts from Streptomyces labedae 20PM against A. hydrophila (in vitro and in vivo). Quantitative analysis showed that the crude extract had stronger anti-quorum-sensing activity in biofilms than the supernatant. Toxicity assessments indicated that both the supernatant and crude extract were non-toxic (24-hour LC

Indexed as

Aeromonas hydrophilaAnti-Bacterial AgentsBiofilmsCichlidsFish DiseasesGram-Negative Bacterial InfectionsStreptomycesAnimalsQuorum SensingAnti-Bacterial AgentsAeromonas hydrophilaAntibiofilmQuorum sensingStreptomycesTilapia

Identifiers

PMID41691298

DOI10.1186/s13104-026-07713-w

PMCPMC13011324

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LicenceCC BY-NC-ND

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