Evidence map›Paper›PMID 41691281›Full record

ArticleGut pathogens2026

Shigella flexneri 1c bacteremia in a child: a case report.

Mehrzad Sadredinamin, Zohreh Ghalavand, Maryam Rostamyan, Raana Kazemzadeh Anari, Seyyed Mohammadreza Hosseini Imeni, Bahram Nikmanesh

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Article in Gut pathogens, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Mehrzad SadredinaminDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Zohreh GhalavandDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Maryam RostamyanDepartment of Pediatrics Infectious Diseases, Pediatrics Center of Excellence, Hakim Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Raana Kazemzadeh AnariDepartment of Microbiology, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Seyyed Mohammadreza Hosseini ImeniStudent Research Committee, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Bahram NikmaneshDepartment of Medical Laboratory Sciences, School of Allied Medical Sciences, Tehran University of Medical Sciences, Tehran, Iran. b-nikmanesh@tums.ac.ir.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundShigellosis is a significant public health issue in developing countries, particularly affecting young children under the age of five. While it primarily causes gastrointestinal infections, there are rare complications, such as bacteremia, that mainly occur in young children. We present a case of dysentery caused by Shigella flexneri serotype 1c, followed by bacteremia. CASE PRESENTATION: A 13-month-old Afghan child presented with fever, dysentery, distended abdomen, mild tenderness, and dehydration. He did not respond to empirical treatment with ceftriaxone. However, he was successfully treated with a combination of gentamicin and ciprofloxacin. This is the first report of a patient in Iran who was positive for S. flexneri serotype 1c and harbored the ipaB, ipaC, ipaD, ipaH, ipgD, virA, and sen virulence factors.

conclusionsThis case alerts clinicians to consider the possibility of Shigella bacteremia in young children. Early and accurate diagnosis can improve management and prognosis to reduce the risk of fatality outcomes. Additionally, it emphasizes the need to characterize the role of Shigella spp. virulence genes in causing bacteremia.

Indexed as

BacteremiaChildrenDiarrheaSerotypingShigella flexneriVirulence factors

Identifiers

PMID41691281
PMCPMC12961823

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