ArticleThrombosis journal2026
The relationships between disseminated intravascular coagulation and time series change of Von Willebrand factor in patients with out-of-hospital cardiac arrest: a retrospective observational study.
Article in Thrombosis journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundOut-of-hospital cardiac arrest (OHCA) is frequently complicated by disseminated intravascular coagulation (DIC), which worsens outcomes. Von Willebrand factor (VWF) is central to haemostasis, and its multimeric size and activity are regulated by ADAMTS13. Decreased ADAMTS13 activity leads to accumulation of ultralarge VWF multimers and microvascular thrombosis. After OHCA, elevated VWF antigen (VWF Ag) and reduced ADAMTS13 activity have been observed and correlate with poor outcomes. However, the relationships among VWF activity, multimer size, and ADAMTS13 activity in DIC after OHCA remain unclear.
methodsThis single-centre retrospective study included adult patients with witnessed cardiogenic OHCA admitted to the Hokkaido University Hospital between September 2019 and January 2023. Patients receiving extracorporeal membrane oxygenation were excluded. Plasma samples collected from Day 0 (upon arrival at the emergency department) to Day 4 were analysed for VWF Ag, VWF ristocetin cofactor activity (VWF RCo), VWF large multimer index (VWF LMI), and ADAMTS13 activity. Patients were classified into the DIC and the non-DIC groups. Temporal changes in these biomarkers were compared between the two groups, and their associations with DIC scores were assessed.
resultsAmong 28 included patients, 16 fulfilled the DIC criteria upon admission. VWF-Ag and VWF-RCo were markedly elevated in both groups on arrival and continued to rise during the observational period, without significant group differences. The VWF RCo/vWF Ag ratio was decreased in the DIC group. VWF LMI tended to be lower, and ADAMTS13 activity remained consistently reduced in the DIC group compared with the non-DIC group. Increasing DIC scores were associated with higher VWF Ag and lower VWF LMI and ADAMTS13 activity.
conclusionIn patients with OHCA, VWF Ag and functional activity were markedly elevated from the normal range immediately after cardiac arrest. Furthermore, as the severity of DIC increased, ADAMTS13 activity decreased. However, although VWF Ag increased with increasing DIC severity, the multimeric size did not increase but rather decreased. No correlation was observed between VWF activity and DIC severity. These findings do not confirm a causal role of ADAMTS13 and VWF in the pathogenesis of DIC after OHCA.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.