ArticleBMC psychiatry2026
Association of comorbid depressive and anxiety symptoms with cognitive impairment and dementia in Chinese elderly people.
Article in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCognitive impairment is a globally prevalent public health disorder following rapid population aging. Although depression can trigger cognitive decline, few studies have focused on how anxiety and its comorbidity with depression can affect cognitive decline development.
methodsCognitive impairment was recognized based on the Mini-Mental State Examination (MMSE), while dementia was diagnosed with self-/proxy-reported evaluations. The 10-item Center for Epidemiologic Studies Depression Scale (CESD-10) and the 7-item Generalized Anxiety Disorder Scale (GAD-7) were employed for evaluating depressive and anxiety symptoms. The impact of comorbidity on cognitive outcomes was assessed with logistic and linear regression models.
resultsThe study involved 13,792 adults (age ≥ 65 years; mean age: 84.2 ± 11.5 years) from the Chinese Longitudinal Healthy Longevity Survey. Among them, comorbid depressive and anxiety symptoms occurred in 7.7% of older adults. Prevalence was 9.2% for cognitive impairment and 1.4% for dementia. Compared to individuals with only depressive or anxiety symptoms, those with both symptoms exhibited a higher probability of developing cognitive impairment (adjusted OR: 2.07, 95% CI: 1.44, 2.97) and dementia (adjusted OR: 2.55, 95% CI: 1.39, 4.69), with adults aged ≥ 80 years exhibiting a stronger association. Additionally, women, particularly the oldest-old, were at a higher risk of comorbidity-associated dementia. We also observed an identical correlation for MMSE scores, where psychiatric comorbidity correlated significantly with lower scores. The interaction between individual characteristics and depression and anxiety showed no significant effects on cognitive impairment or dementia.
conclusionsComorbidity of depression and anxiety shows an association with dementia and cognitive impairment in Chinese older adults, particularly in oldest-old individuals. Early screening and interventions targeting psychiatric comorbidity may delay dementia progression in this population. CLINICAL TRIAL NUMBER : Not applicable.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.