SynthesisBMC neurology2026
A systematic review of consensus recommendations and guidelines on the management and care of women with multiple sclerosis through pre-pregnancy, pregnancy, and postpartum periods.
Synthesis in BMC neurology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundExpectant mothers with multiple sclerosis (MS) face several challenges during pregnancy and after giving birth. The purpose of this research was to conduct a systematic review aimed at providing a comprehensive set of clinical recommendations for managing and caring for women with MS during pregnancy and the postpartum period.
methodsThe databases of ISI, PubMed, Scopus, and websites of organizations related to Multiple Sclerosis were searched using the keywords Multiple Sclerosis,” “Disseminated Sclerosis,” “Labor,” “Childbirth,“,” child-birth”, “Pregnancy,” “Postpartum,” “Breastfeeding,” " Breast-feeding “,“Delivery,” “Pre-pregnancy,” “Pre pregnancy”, “Family planning,” “Guideline,” “Consensus Statement*”, “Code* of Practice,” and “Practical Guidance, without time limit up to September 2025. All guidelines, best practices, and consensus recommendations regarding MS and pregnancy and postpartum were included in the study. The included documents were reviewed and extracted data were qualitatively synthesized.
resultsAnalysis of 10 documents revealed seven consensus recommendations, one formal expert consensus, one practical recommendation and one guideline. Two of these documents focused specifically on France and two on the United Kingdom, while the remaining six originated from Saudi Arabia, Argentina, the United States, Italy, Switzerland and Australia and New Zealand. The information obtained from the reviewed documents was categorized into six main categories: Pre-pregnancy Considerations, Pregnancy Considerations, Delivery, Postpartum Considerations, Symptomatic Treatments, and Magnetic resonance imaging (MRI) and Monitoring.
conclusionsThis study identifies significant gaps in the care of women with MS from pre-pregnancy to the postpartum period. Despite a consensus on the importance of multidisciplinary, patient-centered care, particularly in patient participation, comprehensive care coverage, and coordinated recommendations for Disease-Modifying Therapies management, these gaps persist. Future guidelines should incorporate active patient involvement, real-world evidence, and psychosocial and educational supports, in addition to clinical interventions, to enhance the quality and safety of care.
trial registrationPROSPERO registration number: CRD420251248093.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.