Evidence map›Paper›PMID 41691148›Full record

ArticleBMC infectious diseases2026

Prevalence of respiratory viruses and nasal colonization by antimicrobial-resistant bacteria among people living with HIV in Ghana.

Mildred Asumamaa Adusei-Poku, Lawrencia Ami Emefa Ativi, Hawawu Ahmed Zakariah, Evelyn Yayra Bonney, Ivy Asantewaa Asante, Nicholas T K D Dayie, George Boateng Kyei, Justice Kwesi Danso, Agnes Oclu, Esimebia Amegashie and 4 more

Abstract read
In one paragraph

Article in BMC infectious diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Mildred Asumamaa Adusei-Poku *Department of Medical Microbiology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
Lawrencia Ami Emefa Ativi *Department of Medical Microbiology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
Hawawu Ahmed ZakariahBacteriology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Evelyn Yayra BonneyVirology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Ivy Asantewaa AsanteVirology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana. iasante@noguchi.ug.edu.gh.
Nicholas T K D DayieDepartment of Medical Microbiology, University of Ghana Medical School, College of Health Sciences, University of Ghana, Accra, Ghana.
George Boateng KyeiVirology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Justice Kwesi DansoBacteriology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Agnes OcluBacteriology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana.
Esimebia AmegashieWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
Osbourne QuayeWest African Centre for Cell Biology of Infectious Pathogens (WACCBIP), Department of Biochemistry, Cell and Molecular Biology, University of Ghana, Accra, Ghana.
Elijah PaintsilDepartment of Pediatrics, Boston University Chobanian & Avedisian School of Medicine, Boston, USA.
Kwasi TorpeyDepartment of Population, Family and Reproductive Health, School of Public Health, University of Ghana, Accra, Ghana.
Beverly EgyirBacteriology Department, Noguchi Memorial Institute for Medical Research, University of Ghana, Accra, Ghana. begyir@noguchi.ug.edu.gh.

Funding

Fogarty International Center and the National Institute of Alcohol Abuse and Alcoholism NIH D43 TW011526 to EPWest African Genetic Medicine Centre (WAGMC) ST/MS/020/2022
6 · The paper itself

Abstract

Respiratory infections are prevalent among individuals with compromised immune systems. While these infections are typically self-limiting, they can cause severe morbidity and mortality among immunocompromised individuals, particularly people living with human immunodeficiency virus (PLWH). Despite the substantial burden of HIV in the sub-Saharan region, there is scarcity of data on respiratory infections among PLWH. Therefore, we carried out a cross-sectional study among PLWH on antiretroviral therapy (ART) in three hospitals in the Greater Accra region of Ghana from January to May 2023. Participants' HIV serostatus was confirmed, and HIV type was determined using Multisure HIV Rapid Test kit (MP Diagnostics). The plasma HIV viral load was measured for each participant. We collected nasopharyngeal and oropharyngeal swab for the detection of bacterial or viral respiratory pathogens. Real time polymerase chain reaction, Matrix-assisted laser desorption/ionization-time of flight (MALDI-TOF) and antimicrobial susceptibility testing were employed. The zone of inhibition for the antimicrobial testing was interpreted according to the CLSI guidelines (CLSI, 2023), 33rd Edition (CLSI_M100-Ed33). Among the 240 participants enrolled, 32% tested positive for at least one respiratory pathogen, while 28% harboured at least one respiratory bacterium. The predominant virus was human coronavirus the Netherlands 63 (HCoV-NL63) detected in 52 (21.7%) participants, Staphylococcus aureus was the prevalent bacteria in 38 (15.8%) of the participants. Notably, we observed the highest co-occurrence (39.1%) of NL63 and S. aureus. We also observed antimicrobial resistant bacteria, particularly against Trimethoprim/Sulfamethoxazole, tetracycline, cephalosporins, ampicillin, chloramphenicol, and ampicillin-clavulanate. The prevalence of respiratory virus or bacteria was not associated with HIV viral load or respiratory symptoms. Bacteria isolated from the nose tended to be antimicrobial resistant.

Indexed as

BacteriaDrug Resistance, BacterialHIV InfectionsRespiratory Tract InfectionsAdultAnti-Bacterial AgentsCross-Sectional StudiesFemaleGhanaHumansMaleMicrobial Sensitivity TestsMiddle AgedNasopharynxPrevalenceViral LoadAnti-Bacterial AgentsAntimicrobial resistanceHIVOpportunistic infectionsRespiratory infections

Identifiers

PMID41691148
PMCPMC13011449

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.